Multidisciplinary Schizophrenia Research Training

项目摘要 这是马里兰州精神病学研究中心第三次竞争性更新T32培训补助金 （MPRC），最初于2003年资助（MH 067533）。拟议计划的目标是准备医学博士，博士 和药学博士感兴趣的基础或临床研究的职业生涯在精神健康的转化研究， 专注于精神分裂症和精神病相关疾病。MPRC，一个有组织的研究中心， 马里兰州大学医学院和精神病学系的分部，是一个最先进的 精神分裂症和相关疾病研究中心，位于斯普林格罗夫 医院中心，一个位于巴尔的摩外的马里兰州住院精神卫生设施。MPRC 研究涉及广泛的综合和转化科学，以调查特定的病理学 与精神分裂症和相关疾病相关，包括;神经生理学，神经影像学，基础 神经化学，啮齿类动物和小型猪的电路建模，疾病病因学， 精神病理学和内在表型，神经认知，实验治疗学和临床试验。的 MPRC的合作框架支持NIMH P50奖项超过30年，最近一次是CIDAR 现在是西尔维奥·O的六年级学生Conte Centerr（2019年秋季）。MPRC的特点是连续 临床前和临床研究者之间的互动和协作-我们共享同一个空间，研讨会 时间表，教师会议和一般的研究兴趣。这一综合经验为几个 教师在MPRC采取积极的作用，支持NIMH研讨会发展行为结构， RDoC倡议和一个PI在这个应用程序是一个高级顾问NIMH分配到RDoC单位。科学 机会和合作是丰富的广泛参与与其他组成部分的 马里兰州大学医学院和药学院以及附近的马里兰州大学 巴尔的摩县（UMBC）。在T32奖学金下提供的博士后培训主要侧重于 精神分裂症和相关疾病的基础神经科学和临床研究。所有受训人员都受过教育 在MPRC的翻译观点，并提供导师和教学培训，在临床 精神病理学和基础神经科学以及结构化的职业规划。我们的独特之处在于 广泛的多学科培训机会（我们唯一接受药学博士），以及具有 非研究重点临床人员纳入课程，以培养科学家务实，真实的 世界需要的领域。MPRC的文化为我们在招聘和管理方面的成功奠定了基础。 培养博士后研究员从事科学事业，包括临床科学家。该计划的毕业生领导 富有成效的、成功的研究密集型职业。这一竞争性的五年续约申请建议， 利用我们以前的成功，继续改进我们的培训方法（包括导师培训）， 培养出多产的、全面发展的、专注于研究的科学家。

Project Summary This is the third competitive renewal of a T32 training grant at the Maryland Psychiatric Research Center (MPRC), originally funded in 2003 (MH067533). The goal of the proposed program is to prepare MDs, PhDs and PharmDs interested in basic or clinical research for a career in translational research in mental health with a focus on schizophrenia and psychosis-related disorders. The MPRC, an Organized Research Center of the University of Maryland School of Medicine and division of the Department of Psychiatry, is a state-of-the-art center for research on schizophrenia and related disorders, located on the grounds of the Spring Grove Hospital Center, a State of Maryland inpatient mental health facility located just outside Baltimore. MPRC research engages a broad range of integrated and translational science to investigate specific pathologies associated with schizophrenia and related disorders including; neurophysiology, neuroimaging, basic neurochemistry, circuitry modeling in rodents and miniature pigs, disease etiology, domains of psychopathology and endophenotypes, neurocognition, experimental therapeutics and clinical trials. The MPRC’s collaborative framework has supported NIMH P50 awards for over 30 years, most recently a CIDAR and presently in year 6 of a Silvio O. Conte Centerr (Fall 2019). The MPRC is characterized by continuous interaction and collaboration among preclinical and clinical investigators- we share the same space, seminar schedules, faculty meetings and general research interests. This integrated experience prepared several faculty at MPRC to take an active role in supporting NIMH workshops developing behavioral constructs for the RDoC initiative and one PI on this application is a senior advisor to NIMH assigned to the RDoC Unit. Scientific opportunities and collaborations are enriched with extensive involvement with other components of the University of Maryland School of Medicine and School of Pharmacy and the nearby University of Maryland Baltimore County (UMBC). Postdoctoral training offered under this T32 fellowship has a primary focus on both basic neuroscience and clinical investigations of schizophrenia and related disorders. All trainees are educated on the translational perspective of the MPRC and provided mentors and didactic training in both clinical psychopathology and basic neuroscience as well as structured career planning. We are unique in that we have a broad array of opportunities for multidisciplinary training (we uniquely accept PharmDs) as well as having nonresearch focused clinical personnel integrated in the curriculum to training scientists in pragmatic, real world needs of the field. The culture at the MPRC provides the foundation for our success in recruiting and training post-doctoral fellows for a scientific career, including clinician scientists. Graduates of the program lead productive, successful research-intensive careers. This competitive five-year renewal application proposes to leverage our previous success and continue to improve our training approach (including mentor training) to produce productive, well-rounded translationally-focused scientists.