Optimizing Implementation in Cancer Control: OPTICC

总体总结 OPTICC(癌症控制优化实施)中心的使命是改善癌症结果 通过支持在癌症控制中优化实施循证干预措施(EBI)。已优化 实施发生在以下情况：(1)用于实施EBI的战略解决了以下关键障碍 在发生实施的特定环境中活跃的实施，以及(2)这些战略 反映解决障碍的最佳可能方法。尽管在执行方面取得了二十年的进展 缺乏支持优化的EBI实施的科学(IS)、实用工具和指导；因此， 战略往往与障碍不匹配，而且往往没有针对有效性、效率或与当地的匹配进行优化 资源。其结果是以浪费时间、精力和资源的形式次优实施，最终， 癌症预后越差。OPTICC中心将推动IS，进而改善EBI在癌症中的实施 通过开发、测试和改进优化EBI实施的创新方法进行控制。OPTICC 中心是华盛顿大学(UW)、Kaiser Permanente Washington Health 弗雷德·哈钦森癌症研究中心(FHCRC)。三个核心将 支持其工作。行政核心将促进多学科合作、卓越的研究和 方法创新。它还将领导中心的外展和传播工作，评估中心的影响，以及 协调中心活动。研究计划核心将进行创新的实施研究，方法 和测量研究，以及推进中心“重大挑战”的小型先导研究的主题是 优化EBI实施。将采取优化EBI实施的三阶段方法-确定 并确定障碍、匹配策略和测试策略的优先顺序--度量开发跨越所有这三个方面 各阶段。实施实验室核心将建立和协调一个由不同的临床和 社区站点进行“体内”IS研究，实施癌症控制EBI，并塑造该中心的研究 议程。该中心的初步研究将集中于优化实施宫颈EBI筛查， 结直肠癌、乳腺癌和卵巢癌。然而，该中心优化EBI实施的方法 将开发、测试和改进可广泛应用于整个癌症护理连续体，用于广泛的癌症， 回答广泛的IS问题。

OVERALL SUMMARY The mission of the OPTICC (Optimizing Implementation in Cancer Control) Center is to improve cancer outcomes by supporting optimized implementation of evidence-based interventions (EBIs) in cancer control. Optimized implementation occurs when: (1) the strategies employed to implement EBIs address the key barriers to implementation that are active in the specific settings in which implementation occurs, and (2) those strategies reflect the best possible methods for addressing the barriers. Despite two decades of progress in implementation science (IS), practical tools and guidance to support optimized EBI implementation are lacking; as a result, strategies are often mismatched to barriers and are often not optimized for effectiveness, efficiency, or fit with local resources. The result is suboptimal implementation in the form of lost time, effort, and resources and, ultimately, poorer cancer outcomes. The OPTICC Center will advance IS and, in turn, improve EBI implementation in cancer control by developing, testing, and refining innovative methods for optimizing EBI implementation. The OPTICC Center is a strategic collaboration of the University of Washington (UW), Kaiser Permanente Washington Health Research Institute (KPWHRI), and the Fred Hutchinson Cancer Research Center (FHCRC). Three cores will support its work. The Administrative Core will promote multidisciplinary collaboration, research excellence, and methodological innovation. It will also lead Center outreach and dissemination efforts, evaluate Center impact, and coordinate Center activities. The Research Program Core will conduct innovative implementation studies, method and measurement studies, and small pilot studies that advance the Center’s “grand challenge” IS theme of optimizing EBI implementation. A three-stage approach to optimizing EBI implementation will be taken—identify and prioritize barriers, match strategies, and test strategies—with measurement development spanning all three stages. The Implementation Laboratory Core will establish and coordinate a network of diverse clinical and community sites to conduct “in vivo” IS studies, implement cancer control EBIs, and shape the Center’s research agenda. The Center’s initial studies will focus on optimizing implementation of screening EBIs for cervical, colorectal, breast, and ovarian cancer. However, the methods for optimizing EBI implementation that the Center will develop, test, and refine can be applied broadly across the cancer care continuum, for a wide range of cancers, to answer a wide range of IS questions.