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中文摘要
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项目概要-行政/方案充实核心 圣地亚哥内森冲击的行政/计划充实核心(Admin Core)的总体目标 中心(SD-NCS)是为了促进和促进对衰老的基本机制的研究,重点是 揭示衰老过程中的异质性。管理核心将作为联系的中心点, 所有可持续发展国家控制系统的活动,维持可持续发展国家控制系统核心之间以及可持续发展国家控制系统核心之间的通信线路, NSC和外部咨询小组,其他内森休克中心(包括内森休克中心) 协调中心(NSC 3)),外部研究社区和其他区域研究中心。的 Admin Core将提供三个关键功能。首先,行政核心将监督三个研究中心的活动。 资源核心,即衰老核心的人类细胞模型,衰老核心的异质性, 老龄化核心的综合模式,以确保为研究者提供高质量和高效率的服务 进行衰老研究这将包括业务和财务监督。管理核心将帮助 协调核心之间的数据和资源流(工作流优化),以及 向研究实验室传播数据和资源。管理核心将执行定期质量控制 评估,监测研究界对核心服务的吸收,并平衡对核心服务的需求。 具有工作流能力的服务。最后,行政核心将协调外部咨询小组的工作, 并执行专家组的建议,以改善核心服务。第二,管理核心将促进 成立研究发展中心,以推行新的老龄化研究项目,并促进教师发展 和培训及其有效行政核心将协调努力,建立和保持一个强大的职业发展 老年研究者计划,重点是初级研究者和已建立的研究者 进入老龄化研究领域。管理核心将帮助运行一个试点赠款计划,运行后勤培训, 研讨会,并促进导师计划。将监测这些方案的有效性, 由管理核心进行评估,并根据执行人员的输入对这些活动进行调整 委员会和外部咨询小组。第三,行政核心将组织和监督 SD-NSC。这将包括建立和维护一个网站,宣传SD-NSC核心服务, 国家安全委员会的成就;与国家安全委员会3、其他国家安全委员会、三个参加国家安全委员会的国家安全委员会广泛交流 机构和其他区域研究中心促进合作;与索尔克 传播办公室宣传SD-NSC的成就;组织讲座,研讨会,播客, 以及社区活动,广泛宣传老龄化研究的重要性。最后,为了实现这些 管理核心将提供项目管理服务,以确保SD-NSC的三个阶段: 按时完成安装、启动和运行,并实现可交付成果。这将包括收集 与所有SD-NSC活动相关的可量化指标,以衡量与NSC 3合作的成功。
英文摘要
PROJECT SUMMARY – Administrative/Program Enrichment Core The overall goal of the Administrative/Program Enrichment Core (Admin Core) of the San Diego Nathan Shock Center (SD-NCS) is to facilitate and promote research into the basic mechanisms of aging, with an emphasis on revealing heterogeneities in the aging process. The Admin Core will serve as the central point of contact for all SD-NCS activities, maintaining lines of communication between SD-NSC Cores, as well as between SD- NSC and the External Advisory Panel, other Nathan Shock Centers (including the Nathan Shock Centers Coordinating Center (NSC3)), the external research community, and other regional research Centers. The Admin Core will serve three key functions. First, the Admin Core will oversee activities of the three Research Resource Cores, namely the Human Cell Models of Aging Core, the Heterogeneity of Aging Core, and the Integrative Models of Aging Core, to ensure that high quality and efficient services are provided to investigators performing aging research. This will include both operational and financial oversight. The Admin Core will help to coordinate the flow of data and resources between Cores (workflow optimization), as well as the dissemination of data and resources to research labs. The Admin Core will perform regular quality control assessments, monitor the uptake of Core services by the research community, and balance demand for Core services with workflow capacity. Finally, the Admin Core will coordinate efforts of an External Advisory Panel and implement panel recommendations to improve Core services. Second, the Admin Core will facilitate efforts of the Research Development Core to launch new aging research projects and to promote faculty development and training. The Admin Core will coordinate efforts to establish and maintain a robust career development program for aging investigators, with an emphasis on junior investigators and established investigators entering the aging research field. The Admin Core will help run a pilot grant program, run logistics for training workshops, and facilitate a mentorship program. Effectiveness of these programs will be monitored and evaluated by the Admin Core, and adjustments made to these activities based on input from the Executive Committee and External Advisory Panel. Third, the Admin Core will organize and oversee outreach activities of the SD-NSC. This will include establishing and maintaining a website to advertise SD-NSC Core services and NSC accomplishment; interfacing extensively with NSC3, other NSCs, the three SD-NSC participating Institutions, and other regional research Centers to foster collaborations; working with the Salk Communications Office to publicize SD-NSC accomplishments; and organizing lectures, symposia, podcasts, and community events to widely broadcast the importance of aging research. Finally, to accomplish these tasks, the Admin Core will provide project management services to ensure the three Phases of SD-NSC set- up, launch, and operation are completed on time and that deliverables are achieved. This will include collection of quantifiable metrics relevant to all SD-NSC activities to measure success in collaboration with NSC3.
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Project 1: The role of mitochondrial stress in liver aging and cancer progression and intervention via oxidative mitohormesis
Project 1: The role of mitochondrial stress in liver aging and cancer progression and intervention via oxidative mitohormesis
San Diego Nathan Shock Center
Diversity Candidate Research Supplement to Study Human Cell Models of Aging
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