Administrative Core

管理核心摘要/摘要 为了运行一个有凝聚力的，协调的和有效的计划项目，临床，研究，技术， 该方案的数据库/统计和报告组成部分需要中央协调。行政 本计划项目（PPG 4）拟议第三次更新的核心内容提供了组织结构， 整合项目核心和研究。成功的另一个关键管理职能是 与其他研究项目的联系，该项目的成功依赖于该项目。在PPG 4的情况下，所有 受试者将从两个来源招募到临床核心：1）匹兹堡大学阿尔茨海默氏症 疾病研究中心（ADRC）和2）Pitt+Me®研究参与者登记处。PPG4 行政核心将与ADRC的行政核心对接，ADRC现已进入第36个年头， 一个大型的、运转良好的临床和基础研究实体。PPG 4极大地利用了ADRC 操作和促进这种相互作用的事实是PPG 4的两个mPI，Cohen博士和Aizenstein博士都 作为ADRC的核心/组件方向，Ikonomovic博士和Villemagne博士都担任 ADRC内部的合作研究者。此外，共同研究者洛佩斯博士是ADRC的共同主任，沿着 科夫勒医生一起做的同样非常重要的是，Snitz博士，临床核心的共同领导人， PPG 4（和PPG 3），担任ADRC的监督神经心理学家。此外，Leslie Dunn 担任ADRC和本计划项目的总管理员。这种连续性将允许 受试者经历了一个相对无缝的过渡到PPG 4研究计划。行政 核心为所有活动的规划和实施提供组织结构和领导 旨在实现计划项目的目标。行政核心的具体目标是：（1） 监督所有计划项目职能（安排会议、设置和评估里程碑、数据 要求，解决冲突，并确保计划项目调查人员和工作人员之间的公开沟通）。 (2)计划项目预算管理，包括支出和资金分配， 核心资源的优先次序和分配。(3)监控遵守联邦和 大学的政策和程序，如NIH公共访问政策，数据共享计划和冲突， 兴趣(4)监测人类受试者研究的依从性，包括与匹兹堡大学的联络 人类研究保护办公室，匹兹堡大学教育和合规支持 人类受试者研究(5)管理所有向匹兹堡大学人类研究所提交的报告 美国食品药品监督管理局保护办公室（[18 F] MK 6240、[11 C]PiB和[18 F]SMBT-1 IND）; Cerveau（[18F]MK6240 MTA）。(6)对计划项目数据库进行行政监督。(7)联络 匹兹堡大学ADRC神经病学系。(8)组织外部咨询会议。

Admin Core Summary/Abstract To operate a cohesive, coordinated and effective Program Project, the clinical, research, technology, database/statistics and reporting components of the program require central coordination. The Administrative Core of the proposed third renewal of this Program Project (PPG4) provides the organizational structure and integration of the Program Project Cores and research. Another administrative function critical for success is to liaison with other research programs on which the Program Project relies for success. In the case of PPG4, all subjects will be recruited to the Clinical Core from two sources: 1) the University of Pittsburgh Alzheimer’s disease Research Center (ADRC) and 2) The Pitt+Me® Research Participant Registry. The PPG4 Administrative Core will interface with the Administrative Core of the ADRC, which is now in its 36th year and is a large and smoothly functioning clinical and basic research entity. PPG4 greatly leverages the ADRC operations and facilitiating this interaction is the fact two mPIs of PPG4, Dr. Cohen and Dr. Aizenstein both serves as Core/ Component directions within the ADRC and Dr. Ikonomovic and Dr. Villemagne both serve as co-Investigators within the ADRC. Further, co-Investigator, Dr. Lopez is the Co-director of the ADRC, along with co-Investigator Dr. Kofler. Also very important is the fact that Dr. Snitz, co-Leader of the Clinical Core of PPG4 (and of PPG3), serves as the supervising neuropsychologist in the ADRC. Furthermore, Leslie Dunn serves as the overall Administrator for both the ADRC and this Program Project. This continuity will allow for the subjects to experience a relatively seamless transition into the PPG4 research program. The Administrative Core provides the organizational structure and leadership for planning and implementation of all activities aimed at the fulfillment of the Program Project aims. The specific aims of the Administrative Core are: (1) Supervision of all Program Project functions (scheduling meetings, setting and evaluating milestones, data requests, resolving conflict and ensuring open communication among Program Project investigators and staff). (2) Management of Program Project budget, including expenditures and allocation of funds according to Program Project priorities and distribution of Core resources. (3) Monitor compliance with Federal and University policies and procedures, such as NIH Public Access Policy, Data Sharing Plan, and Conflict of Interest. (4) Monitor compliance with Human subjects research, including liaising with University of Pittsburgh Human Research Protections Office, the University of Pittsburgh Education and Compliance Support for Human Subject Research. (5) Manage all reporting to the University of Pittsburgh Human Research Protections Office, the Food and Drug Administration ([18F]MK6240, [11C]PiB, and [18F]SMBT-1 INDs); Cerveau ([18F]MK6240 MTA). (6) Administrative oversight of the Program Project Database. (7) Liaise with the University of Pittsburgh ADRC in the Department of Neurology. (8) Organize External Advisory Meetings.