PAHs: New Technologies and Emerging Health Risks

总结-总体中心 俄勒冈州州立大学超级基金研究计划（SRP），与太平洋西北大学合作 国家实验室和其他利益相关者和合作者，寻求开发新技术， 确定在美国许多超级基金场所发现的多环芳烃混合物 修复前后。我们将确定新的危害和毒性机制的多环芳烃和现实世界 PAH混合物。SRP将支持三个生物医学研究项目和两个环境科学项目， 工程项目。我们将这些研究项目与SRP的四项任务相结合， 超级基金网站的挑战。行政，社区参与，化学混合物，研究 经验和培训，以及数据管理和分析核心支持研究项目。这 我们的建议是建立在我们在上一个赠款期间取得的成功之上的。未来五年，我们将继续 创新的、高影响力的研究目标。例如，我们建议（1）开发第一个可推广的 技术来测量多环芳烃的移动和从超级基金网站，（2）测量外部暴露 多环芳烃的个人附近的超级基金网站，并确定他们的暴露如何变化的功能， （3）预测生物和非生物降解过程中PAHs的二次转化产物 修复在超级基金网站，（4）预测复杂的多环芳烃混合物的毒性使用斑马鱼，（5）链接 在强大的人体体外呼吸模型的帮助下，PAH暴露于健康结局，以及（6） 阐明毒性系统中PAH易感性的代谢和物理化学控制。核心将（1） 指导战略审查进程的活动，并向利益攸关方传播我们的调查结果（行政）， 受PAH暴露影响的社区，以解决问题并降低风险（社区参与）;（3） 为下一代环境健康科学家提供密集的多学科培训 （RETCC），（4）提供数据管理和分析支持（DMAC），以及（5）应用最新技术 化学仪器和方法来测量环境中发现的多环芳烃和多环芳烃混合物， 生物基质通过实现这些目标，我们将推进科学前沿，并提高 受影响社区的生活质量。

SUMMARY – OVERALL CENTER The Oregon State University Superfund Research Program (SRP), in partnership with Pacific Northwest National Laboratories and other stakeholders and collaborators, seeks to develop new technologies to identify the polycyclic aromatic hydrocarbon (PAHs) mixtures found at many of the nation's Superfund sites before and after remediation. We will identify novel hazard and toxicity mechanisms for PAHs and real-world PAH mixtures. The SRP will support three biomedical research projects and two environmental science and engineering projects. We aligned these research projects with the four SRP mandates to address pressing challenges at Superfund sites. The Administrative, Community Engagement, Chemical Mixtures, Research Experience and Training, and Data Management and Analysis cores support the research projects. This proposal builds on our successes during the previous grant period. Over the next five years, we will pursue innovative, high-impact research goals. For example, we propose to (1) develop the first generalizable technology to measure the movement of PAHs to and from Superfund sites, (2) measure external exposures to PAHs for individuals near Superfund sites and determine how their exposures vary as a function of location, (3) predict the secondary transformation products of PAHs that will form during biotic and abiotic remediation at Superfund sites, (4) predict the toxicity of complex PAH mixtures using zebrafish, (5) link PAH exposure to health outcomes with the aid of a powerful human in vitro respiratory model, and (6) elucidate metabolic and physicochemical control of PAH susceptibility in toxicity systems. The cores will (1) direct the activities of the SRP and disseminate our findings to stakeholders (Administrative), (2) work with communities impacted by PAH exposure to address concerns and reduce risk (Community Engagement); (3) provide intensive multi-disciplinary training for the next generation of Environmental Health Scientists (RETCC), (4) provide data management and analysis support (DMAC), and (5) apply state-of- the-art chemistry instrumentation and approaches to measure PAHs and PAH mixtures found in environmental and biological matrices. By accomplishing these goals, we will advance the frontiers of science and also improve the quality of life for impacted communities.