UNC Chemical Biology Interface Training Program

摘要 我们建议建立一个化学-生物学接口（CBI）培训计划，使学员能够在 位于查佩尔山的北卡罗来纳州大学（北卡罗来纳州），以获得科学培训的广度， 现代的、机械的化学生物学。该计划借鉴了两个历史上成功的 化学生物学和药物化学部（CBMC），位于Eshelman 药学院、生物化学系、有机化学系 （艺术与科学学院）。这两个单位有着牢固和持续的合作传统， 共同的课程，和一个共享的研讨会系列。尽管科学家们有着高度重视的科学传统， 美国国立卫生研究院的校园里没有以化学为导向的培训项目。该计划将带来 共有25名研究人员，他们涵盖了化学生物学的广度，从分析 生物分析到蛋白质结构/功能到药物化学/药物设计。此外，三位有前途的年轻人 教师将作为“指导导师”加入该计划，与资深同事密切合作，因为他们 继续制定自己的方案。项目负责人，一个来自CBMC，一个来自 化学，是有指导和行政经验的资深教师完成;他们将提供 由内部指导委员会和一个杰出的外部小组提供投入的方案指导 顾问。学生将从两个主要单位和一个生物/生物医学的伞招募 在招收优秀和多样化的研究生方面取得了显着成功的科学计划 到校园。培训计划包括（1）建立研究基础的共同课程 在化学-生物学界面，包括负责任地进行研究和严格/再现性培训， (2)在期刊俱乐部和较小的讨论小组之间交替举行的双周会议，重点是 个人学习和专业发展，（3）秋季前举行的计划务虚会 学期，提供方向和早期正式培训的严谨性和可重复性，和（4）受训者组织 研讨会将成为一个重要的年度活动，在北京举行。化学生物学界面的研究 变得越来越重要，因为我们对生物学的理解需要更多的分子见解。 因此，拟议计划的活动将利用CBMC的各种专业知识， 化学，以及广泛的教育和研究资源，可在这一国际 认可的机构。该计划将从以下角度为学员提供上级教育： 深度和广度，并在化学和生物学的界面上培养训练有素的博士学者，他们将 在学术界和工业界的生物医学科学中发挥关键作用。

ABSTRACT We propose to establish a Chemistry–Biology Interface (CBI) Training Program that will enable trainees at the University of North Carolina at Chapel Hill (UNC) to obtain the breadth of scientific training essential for modern, mechanistically informed chemical biology. This program draws from two historically successful programs at UNC: the Division of Chemical Biology and Medicinal Chemistry (CBMC) in the UNC Eshelman School of Pharmacy, and the Biological and Organic Chemistry Divisions in the UNC Department of Chemistry (College of Arts and Sciences). These two units have a strong and continuing tradition of collaboration, common coursework, and a shared seminar series. Although UNC has a highly regarded scientific tradition, there is no chemistry-oriented NIH training program on the UNC campus. The proposed program will bring together 25 established researchers who encompass the breadth of chemical biology, ranging from analytical bioanalysis to protein structure/function to medicinal chemistry/drug design. In addition, three promising junior faculty members will join the program as “mentored mentors”, working closely with senior colleagues as they continue to establish their programs. The program leaders, one from CBMC and one from the Department of Chemistry, are accomplished senior faculty with mentoring and administrative experience; they will provide program guidance with input from an internal steering committee and a distinguished group of external advisors. Students will be recruited from the two primary units and from a UNC umbrella biological/biomedical sciences program that has shown remarkable success in recruiting outstanding and diverse graduate students to the campus. The training program includes (1) common coursework that establishes the basis for research at the chemistry–biology interface, including responsible conduct of research and rigor/reproducibility training, (2) biweekly meetings that alternate between a journal club and a smaller discussion group focused on individual learning and professional development, (3) an program retreat that will be held before the fall semester, providing orientation and early formal training in rigor and reproducibility, and (4) a trainee-organized symposium that will become a major annual event at UNC. Work at the chemistry–biology interface has become increasingly relevant as our understanding of biology has required more molecular insights. Accordingly, the activities of the proposed program will capitalize on the diverse expertise in CBMC and Chemistry, and the extensive educational and research resources that are available at this internationally recognized institution. This program will provide trainees with a superior education from the perspective of depth and breadth, and develop well-trained PhD scholars at the interface of chemistry and biology who will play a critical role in the biomedical sciences across academia and industry.