P20 Exploratory Center for Precision Health in Diverse Populations

摘要/项目摘要 行政核心 本提案响应RFA-NR-10-002：NINR探索中心(P20)。我们建议的总体目标是 纽约大学迈耶斯P20探索中心在不同人群中的精确健康是为了改善健康 通过解决生物多样性和共同的机制、症状、可改变因素和 代谢综合征(METS)和由此导致的2型糖尿病(T2D)的不可改变因素，心血管 疾病(CVD)和相关的同时发生且复杂的多种慢性病(MCC) 诊断和治疗。我们将从精确生态的角度来处理这项工作。其中一些最重要的 实施这项工作的主要障碍是确定如何最好地让不同社区参与进来 在科学和生物行为、基因组、背景、生活方式和家庭因素方面与METS和MCC有关 以及如何最好地进行干预和降低风险。我们将在历史上不同的群体中进行这项研究 在研究中代表性不足，包括种族/少数民族、儿童、妇女、老年人和其他 弱势群体。其他特征，如性取向(LGBQ)、性别认同(非独联体或 (变性人)、残疾状况、宗教或精神、社会经济地位弱势背景和原籍国 也将在我们的研究中考虑。该中心的行政核心专注于支持以下研究 在现实世界中解决这些问题，在不同人群中应用精确的生态方法 以改善公众健康。 行政核心将负责协调和监督科学和行政 中心的活动，包括总体目标、内部和外部沟通、合规、 评估和可持续性。我们将评估中心的生产力、有效性和适宜性 活动；确定中心关联的标准，并促进整个纽约大学与研究人员的合作 研究蛋氨酸、T2D、心血管疾病及相关慢性病。所有活动都将与中心的总体目标保持一致 支持对生物多样性和共同的机制、症状、可改变因素和 不可修改的因素，作为METS和相关MCC的基础，以改善医疗保健结果并减少 健康差距。

Abstract/Project Summary ADMINISTRATIVE CORE This proposal responds to RFA-NR-10-002: NINR Exploratory Center (P20). The overall goal of our proposed NYU Meyers P20 Exploratory Center for Precision Health in Diverse Populations is to improve health outcomes by addressing biologically diverse and common mechanisms, symptoms, modifiable factors, and non-modifiable factors of metabolic syndrome (MetS) and resulting type 2 diabetes (T2D), cardiovascular disease (CVD), and related multiple chronic conditions (MCC) that occur simultaneously and complicate diagnosis and treatment. We will approach this work from a precision ecological perspective. Some of the most significant barriers to implementation of this work are in determining how best to engage diverse communities in the science and of biobehavioral, omic, contextual, lifestyle and familial factors implicated in MetS and MCC and how best to intervene and reduce risks. We will conduct this research in diverse groups that are historically under-represented in research, including racial/ethnic minorities, children, women, elderly, and other vulnerable populations. Other characteristics such as sexual orientation (LGBQ), gender identity (non-cis or transgender), disability status, religion or spirituality, SES-disadvantaged backgrounds, and country of origin will also be considered in our research. The Center's Administrative Core is focused on supporting research to address these issues in real world applications of a precision ecological approach among diverse populations to improve public health. The Administrative Core will be responsible for coordinating and overseeing the scientific and administrative activities of the Center, including the overall aims, internal and external communications, compliance, evaluation, and sustainability. We will evaluate the productivity, effectiveness, and appropriateness of Center activities; determine criteria for center affiliations, and foster collaborations throughout NYU with researchers studying MetS, T2D, CVD, and related chronic conditions. All activities will align with the Center's overall goal of supporting research on biologically diverse and common mechanisms, symptoms, modifiable factors, and non-modifiable factors that underlie MetS and related MCC, to improve health care outcomes and reduce health disparities.