A virtual platform for animal–human inhalation toxicity extrapolation

该项目旨在通过开发一个集成的虚拟平台，消除从动物到人类的数据外推的长期障碍。该项目预计将完全解决常用动物代理人和人类之间鼻呼吸道吸入暴露的差异，这可能为开发严格的物种间数据转换计划奠定科学基础。预期结果包括可在任何呼吸道隔间实施的多功能吸入暴露风险评估工具、提高动物试验的可靠性、减少用于试验的动物数量。这将在改善职业健康和安全以及促进国家/国际法规改革方面提供重大好处。

This project aims to remove the long-lasting barrier in extrapolating data from animals to humans by developing an integrated virtual platform. This project expects to fully resolve inhalation exposure differences in nasal airways between commonly used animal surrogates and humans, which could lay scientific underpinnings in developing rigorous interspecies data conversion schemes. Expected outcomes include a versatile inhalation exposure risk assessment tool that can be implemented for any airway compartment, enhanced reliability of animal tests, reduced number of animals for testing. This should provide significant benefits in improving occupational health and safety and promoting National/International regulatory changes.