XtremeCT II high-resolution peripheral quantitative computed tomography (HR-pQCT) scanner

项目摘要 在此共享仪器赠款申请中，我们正在申请资金以获得XtremeCT II High 分辨率外周定量CT(HR-pQCT)扫描仪。HR-pQCT是一种非侵入性、 用低辐射方法评估骨室比体积骨密度和骨 在外周骨骼中的微架构，以评估骨强度和骨折风险。这一状态的整合- 在维克森林公司提供的生物医学成像工具系列中加入最先进的骨骼成像模式 医学院(WFSM)推进了NIH资助的18个中心、研究所和院系的倡议； 加强与我们几个地区合作伙伴的合作努力。具体地说，收购HR-pQCT 技术将允许建议的主要和次要用户群体：1)更好地了解生活方式的影响- 基于负重运动和高蛋白饮食等策略对老年人骨骼健康的影响 成人减肥；2)扩大对年龄相关生物变化在骨骼肌中作用的调查 关于移动性的下降，包括与骨骼的互动；3)展示高级图像的潜力 分析增强组织结构结果的技术；4)提供对 骨骼健康，帮助开发新的治疗策略，以减轻衰老过程中的骨丢失；5)更好 捕获机动车碰撞乘员的肌肉骨骼并存，并了解它们对 伤害发生率和康复成功；6)解决体重管理效果方面的重要差距 对成长中的骨骼进行干预；7)评估骨骼微结构是否因种族而异 多样化的人群；8)增强计算建模策略，评估不同人群骨骼健康的变化 寿命，包括骨骼微结构和强度；以及9)决定时间和程度 在患有糖尿病和慢性肾脏疾病的成年人中，会发生皮质内骨丢失。提升成本 为了提高效率，鼓励最佳共享，并促进多学科合作，HR-pQCT将 位于WFSM的翻译成像计划核心，在那里将由合格的领导层监督， 业务和咨询委员会按照组织严密和自我维持的行政和 财务计划。最终，增加HR-pQCT系统将使WFSM能够参与更多 多学科协作，更成功地竞争外部研究资金，并留在 肌肉骨骼研究的前沿领域。

Project Abstract In this Shared Instrument Grant application, we are requesting funds to acquire an XtremeCT II High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) scanner. HR-pQCT is a non-invasive, low radiation approach for assessing compartment-specific volumetric bone mineral density (vBMD) and bone microarchitecture in the peripheral skeleton to estimate bone strength and fracture risk. Integration of this state- of-the-art skeletal imaging modality into the repertoire of biomedical imaging tools available at Wake Forest School of Medicine (WFSM) advances the initiatives of 18 NIH-funded centers, institutes, and departments; and bolsters collaborative efforts with several of our regional partners. Specifically, acquisition of HR-pQCT technology will allow the proposed major and minor user groups to: 1) better understand the effects of lifestyle- based strategies — such as weight-bearing exercise and a high protein diet — on skeletal health among older adults losing weight; 2) expand the investigation of the role of age-related biological changes in skeletal muscle on the decline in mobility to include interactions with bone; 3) demonstrate the potential of advanced image analyses techniques to augment histostructural outcomes; 4) provide insight into the genomic architecture of bone health to aid in the development of novel treatment strategies to mitigate bone loss in aging; 5) better capture musculoskeletal comorbidities among motor vehicle crash occupants, and understand their influence on injury incidence and rehabilitation success; 6) address important gaps on the effects of weight management interventions on the growing skeleton; 7) evaluate whether bone microarchitecture varies across ethnically diverse populations; 8) augment computational modeling strategies assessing change in bone health across the lifespan to include bone microarchitecture and strength; and 9) determine the timing of and extent to which intracortical bone loss occurs among adults with diabetes mellitus and chronic kidney disease. To promote cost effectiveness, encourage optimal sharing, and foster multidisciplinary collaborations, the HR-pQCT will be housed in the Translational Imaging Program Core at WFSM, where it will be overseen by qualified leadership, operational, and advisory committees in accordance with well-organized and self-sustaining administrative and financial plans. Ultimately, the addition of a HR-pQCT system will enable WFSM to engage in more multidisciplinary collaborations, compete more successfully for external research funding, and remain at the forefront of musculoskeletal research endeavors.