Longitudinal Study of Health and Ageing in Kenya (LOSHAK)

拟议的项目旨在建立成功开展健康纵向研究所需的基础设施 和肯尼亚老龄化（LOSHAK），一项在肯尼亚年龄≥45岁的成年人中开展的基于人群的队列研究。这将是 健康与退休研究（HRS）网络中关于老龄化的协调研究的一项新研究。关键重点领域 LOSHAK将包括阿尔茨海默病和相关痴呆症（ADRD），心理健康，健康和 气候变化和空气污染的经济影响，以及影响晚年经济福祉的因素。 肯尼亚目前人口相对年轻，但人口老龄化速度很快 在接下来的30年里。因此，也必须开始研究人口一级的趋势 作为个人老龄化轨迹，以表征健康，残疾和福祉的风险因素， 肯尼亚背景。重要的是，撒哈拉以南非洲人口层面的老龄化数据存在重大差距，而且 LOSHAK将是HRS网络在该地区的第二项研究。为了执行拟议的 基础设施发展的目标，我们将利用我们的研究小组正在进行的流行病学监测平台， 肯尼亚沿海地区的Kaloleni/Rabai社区卫生和人口监测系统， 其中包括超过14，000名年龄≥45岁的个体。在本申请中，我们提出以下目的： 1)调整和验证现有HRS网络措施以及新的调查和数据收集协议（分子 生物标志物，生理措施）; 2）设计LOSHAK的第1波，包括采样 制定一项长期战略计划， 扩大到一个具有全国代表性的小组研究老龄化在肯尼亚的第二波LOSHAK。的 KRHDSS平台将使我们能够有效地招募和登记参与者，并将有助于我们的成功 实现这些目标。在整个基础设施开发过程中，我们将与HRS密切合作， 和HRS姐妹研究网络，以便最大限度地提高与措施和流程的可比性（例如， HRS面试管理培训，计算机辅助个人面试软件的使用，数据 处理等）用于其他HRS网络研究。因此，LOSHAK最终将提供基于人口的关键 以及从中年到晚年的健康和经济福祉的综合措施。这些数据将 为了能够与高收入国家和其他中低收入国家进行跨国比较， 因此，扩大了在全球范围内了解健康和老龄化的机会。

The proposed project aims to build the infrastructure needed to successfully field the Longitudinal Study of Health and Ageing in Kenya (LOSHAK), a population-based cohort study of adults age ≥45 years in Kenya. This will be a new study in the Health and Retirement Study (HRS) network of harmonized studies on aging. Key focus areas of LOSHAK will include Alzheimer’s disease and related dementias (ADRD), mental health, the health and economic impacts of climate change and air pollution, and factors influencing late-life economic well-being. Kenya currently has a relatively young population, but is poised to experience very rapid aging of its population over the next 30 years. Accordingly, it is vitally important to begin studying both population-level trends, as well as individual aging trajectories in order to characterize risk factors for health, disability, and well-being in the Kenyan context. Importantly, there is a major gap in population-level data on aging in Sub-Saharan Africa, and LOSHAK will be only the second study in the HRS Network from the region. In order to carry out the proposed infrastructure development aims, we will leverage our study team’s ongoing epidemiologic surveillance platform, the Kaloleni/Rabai Community Health and Demographic Surveillance System (KRHDSS) in coastal Kenya, which includes more than 14,000 individuals age ≥45 years. In this application we propose the following aims: 1) to adapt and validate existing HRS network measures and new survey and data collection protocols (molecular biomarkers, physiological measures) within the KRHDSS; 2) To design Wave 1 of LOSHAK, including a sampling strategy to draw a regionally-representative probability sample; and 3) To develop a long-term strategic plan for expansion towards a nationally-representative panel study of aging in Kenya for Wave 2 of LOSHAK. The KRHDSS platform will enable us to efficiently recruit and enroll participants and will contribute to our success carrying out these aims. Throughout the infrastructure development process, we will work closely with the HRS and the HRS Sister Studies Network in order to maximize comparability with the measures and processes (e.g., training in HRS interview administration, use of computer-assisted personal interviewing software, data processing, etc) used in other HRS network studies. Thus, LOSHAK will ultimately provide key population-based and comprehensive measures on health and economic well-being from mid- to late-life. These data will be harmonized in order to enable cross-national comparisons with high-income and other low- and middle-income countries, thereby expanding opportunities to understand health and aging in a global context.