How do cells sense and react to mechanical forces?

越来越多的证据表明，施加在组织和细胞上的机械力强烈影响它们的行为。我的研究旨在了解细胞如何感知和应对生命中所经历的力量。使用三维细胞和组织培养方法的组合，我将研究压力如何改变细胞的生化和它们的功能。这项工作的目的是产生基础知识，以提高我们对细胞如何对力做出反应的理解。预期的结果是更好地了解细胞和环境之间的机械和生化关系，为组织工程领域的培养支架提供信息，以更好地模拟自然细胞-组织环境。

There is accumulating evidence that mechanical forces exerted on tissues and cells strongly influences their behaviour. My research aims to understand how cells sense and respond to forces experienced throughout life. Using a combination of three-dimensional cell and tissue culture methods, I will investigate how compressive forces change the biochemistry of cells and their functionality. This work is aimed at generating fundamental knowledge to improve our comprehension of how cells respond to force. The expected outcome is a greater understanding of mechanical and biochemical relationships between cells and the environment, to inform fields of tissue engineering of culture scaffolds to better mimic natural cell-tissue settings.