How do stem cells get specified during embryonic muscle development?

干细胞在胚胎肌肉发育过程中如何被指定？

• 批准号: DP240101647
• 负责人: Prof Peter Currie
• 金额: $ 44.26万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101647
• 关键词: How; do; stem; cells; get

This project aims to investigate the mechanisms by which muscle stem cells first form in the embryo. This project expects to generate new knowledge on the mechanism that patterns cell types in the embryonic myotome. Expected outcomes of this project include uncovering the developmental mechanisms of cell type specification in the myotome with specific reference to the generation of stem cells. This should provide significant benefits as it will inform how long lived tissue resident stem cells can be made in the first instance, knowledge that is critical for making stem cells on demand outside the animal and manipulating stem cells in living tissue.

该项目旨在研究肌肉干细胞在胚胎中首次形成的机制。该项目预计将产生有关在胚胎肌病中模拟细胞类型的机制的新知识。该项目的预期结果包括揭示肌动物中细胞类型规范的发育机制，并特别提及干细胞的产生。这将提供重大的好处，因为它将告知首先可以居住多长时间居住的组织居民干细胞，这对于使动物外部的干细胞和操纵生物组织中的干细胞在生存组织外的需求至关重要。