How do cells survive nutrient stress? Insight into mechanisms.

细胞如何在营养压力下生存？

• 批准号: DP220103531
• 负责人: Prof Janni Petersen
• 金额: $ 34.49万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-12-30 至 2025-12-29
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103531
• 关键词: How; do; cells; survive; nutrient

This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.

本项目研究真核生物在营养胁迫下的细胞存活。在大量初步数据的基础上，确定了新的TOR(雷帕霉素靶标)复合体2(TORC2)控制点，它有望产生确保细胞存活的宏观自噬压力控制的关键和保守特征的新知识。它使用跨学科和创新的方法来验证和表征营养胁迫依赖的信号。预期成果包括对细胞增殖的环境控制的新见解，以及打造跨机构合作。这一知识有利于基础生物学和应用生物学，并与利用活细胞作为支持细胞生存和增殖的营养物质的行业/项目有关。