USC/UCLA Center for Biodemography and Population Health: Core B

抽象核心B 计划开发核心(PDC)的总体目标是提供试点资金，以支持 发展创新和开创性的研究，将导致对 影响老年人健康的过程，以及这些过程是如何由生物、 社会、行为、心理、经济、环境和卫生保健条件。先前的试点项目 极大地提高了我们对生活环境、行为、压力源和 DNA遗传学在影响生物结果以及下游健康结果中的作用。项目还包括 在为后续资助的研究和重要出版物提供基础方面极为成功。在……里面 与CBPH的总体目标保持一致，我们已将部分试验计划用于 开发提供更多资源的生物和健康计量和数据创新 对于整个研究界来说。我们建议的第一年试点反映了CBPH目前对 衰老的细胞和分子机制。Pilot 1介绍了RNA转录和生命历程 主题；试点2涉及背景、认知和表观遗传学/炎症主题；试点3涉及细胞 衰老，DNA甲基化和生命历程；飞行员4解决了认知和大脑老化的话题。他们都是 建议使用至少一种新开发的数据：RNA转录组图谱、DNA甲基化、 流式细胞仪和核磁共振数据。PDC也一直是整合和发展的重要机制 生物人口统计学研究人员，包括新兴学者、新教师和过渡到 生物人口学在我们两所大学和更广泛的领域。拟议的飞行员包括来自两个国家的研究人员 其他大学和所有大学都包括一名新兴学者。PDC与联合国儿童基金会的活动紧密结合 行政研究核心(ARC)和我们的研究资源和传播核心(RRDC)。多数 飞行员将工作融入到由ARC组织的全国会议中，一些飞行员要么开始要么 过渡到RRDC中的验证项目。下一个周期的资金将进一步推动 通过开发新的调查人员，招募来自以下领域的知名高级调查人员 其他领域，并扩大人口健康研究中评估的生物参数的范围，所有这些都 目的是更清楚地了解生活体验所影响的生物途径 人口一级的健康和福祉轨迹，并解决#年的严重健康差距 亚种群。

Abstract Core B The overarching aim of the Program Development Core (PDC) is to provide pilot funding to support the development of innovative and ground-breaking research that will lead to a fuller understanding of the processes affecting population health at older ages and how these processes are modified by biological, social, behavioral, psychological, economic, environmental, and health care conditions. Prior pilot projects have significantly increased our understanding of the roles of life circumstances, behaviors, stressors, and DNA genetics in affecting biological outcomes, as well as downstream health outcomes. Projects have also been extremely successful in providing a basis for subsequent funded research and significant publications. In keeping with the overarching aim of the CBPH, we have devoted a subset of our pilot projects to the development of innovations in biological and health measurement and data which provide increased resources for the entire research community. Our proposed pilots for the first year reflect the current CBPH focus on cellular and molecular mechanisms of aging. Pilot 1 addresses the RNA Transcriptomics and Life Course topics; Pilot 2 addresses the Context, Cognition and Epigenetics/Inflammation topic; Pilot 3 addresses the Cell Senesence, DNA Methylation & Life Course; Pilot 4 addresses the Cognition and Brain Aging topic. They all propose the use of at least one type of newly developed data: RNA transcriptome profiling, DNA methylation, flow cytometry, and MRI data. The PDC has also been an important mechanism for integrating and developing biodemographic researchers including emerging scholars, new faculty, and faculty transitioning into biodemography at both our Universities and in the wider field. Proposed pilots include researchers from two other Universities and all include an emerging scholar. The PDC is strongly integrated with the activities of the Administrative Research Core (ARC) and our Research Resource and Dissemination Core (RRDC). Most pilots produce work integrated into our national meetings organized by the ARC and some pilots either begin or transition to validation projects in the RRDC. Funding over the next cycle will further advance the field of Biodemography by developing new investigators, recruiting into the field established senior investigators from other fields, and broadening the range of biological parameters assessed in population health research, all with the aim of understanding more clearly the biological pathways through which lived experience impacts trajectories of health and wellbeing at the population level, and addressing critical health disparities across sub-populations.