Training in Translating Neuroscience to Therapies

项目摘要 这是罗格斯大学“将神经科学转化为疗法的培训”的新项目。它的整体 目标是为科学家提供在实验室进行实验的培训技能和能力 需要将他们的发现推进到神经疾病的治疗上。该计划的目标是：1) 提供连续的综合培训，推动翻译神经科学研究向 治疗发展；2)在不同的领域扩大翻译神经科学研究人员的渠道 学员队列；以及3)利用罗格斯大学在神经科学药物发现和开发方面的优势 为该项目的实习生提供广泛的经验。建立这个项目的基本原理是 全球神经疾病的负担越来越大，其中许多疾病没有很好的治疗方法，更不用说治愈了， 以及神经遗传学和分子发病机制方面的科学发现的加速进展 系统紊乱。因此，现在是利用我们在了解疾病方面所获得的知识的好时机。 流程，填补这个知识库中的空白，并将基本发现转化为患者可交付的成果 患有这些疾病的人。培训计划的设计结合了传统的课程作业、研讨会、 会议、生物统计学课程和年度静修，以及通过一系列经验学习 与将科学创新与工业相联系的领域的专家进行学徒制，以推进实验室 从发现到临床试验。学员将向神经学家和试验者学习，并积极从事临床工作 审判。每名学员的培训期限为两年。第一年总共需要两个职位， 在接下来的几年里有四个职位。受训者将包括高级研究生、医学博士研究生 和博士后研究员的比例为1：1：2。受训人员将在高素质神经科学家的实验室工作 和翻译调查人员使用多学科方法来学习严格和 可重复的研究。他们还将有具有药物化学、药物发现和 开发、临床研究和试验、初创企业和职业机会。教职员工和实习生将受益 来自罗格斯大学生物医学和健康科学的正式指导计划。计划监督 包括内部和外部咨询委员会，以及由以下高级领导层组成的执行委员会 罗格斯大学在翻译和临床研究、药物开发、 创新的商业化，以及研究生教育。的质量和效果 培训计划将由一名独立评估人员进行评估。这项计划的预期结果是 培养下一代翻译神经科学领域的领导者，他们拥有专业知识和激情 临床试验和治疗的基本发现，使数百万神经疾病患者受益。

Project Summary This is a new program for “Training in Translating Neuroscience to Therapies” at Rutgers University. Its overall objective is to provide scientists in training performing laboratory-based experiments the skills and competencies needed to advance their discoveries to treatments for neurological disorders. The aims of the program are to: 1) provide a continuum of comprehensive training that advances translational neuroscience research towards therapeutic developments; 2) expand the pipeline of translational neuroscience researchers within a diverse cohort of trainees; and 3) leverage Rutgers’ strengths in neuroscience drug discovery and development to provide broad experiences to trainees in this program. The rationale for establishing this program is the increasing burden of neurological diseases globally, many of which have no good treatments much less cures, and the accelerated advances in scientific discoveries in the genetics and molecular pathogenesis of nervous system disorders. Thus, this is an opportune time to harness knowledge gained in our understanding of disease processes, fill in the gaps in this knowledge base, and translate basic discoveries to deliverables for patients suffering from these disorders. The design of the training program combines traditional coursework, seminars, conferences, a biostatistics curriculum, and an annual retreat, along with experiential learning through a series of apprenticeships with experts in fields that link scientific innovation with industry to advance laboratory discoveries to clinical trials. Trainees will learn from neurologists and trialists, and actively engage in clinical trials. The training period for each participant is two years. A total of two positions are requested in year one, and four positions in subsequent years. The trainees will include senior graduate students, MD/PhD students and postdoctoral fellows at a ratio of 1:1:2. Trainees will work in the laboratories of highly qualified neuroscientists and translational investigators employing multidisciplinary approaches to learn the principles of rigorous and reproducible research. They will also have mentors with expertise in medicinal chemistry, drug discovery and development, clinical research and trials, start-ups, and career opportunities. Faculty and trainees will benefit from a formal mentoring program in place at Rutgers Biomedical and Health Sciences. Program oversight includes internal and external advisory boards, and an Executive Committee consisting of senior leadership at Rutgers University with extensive experience in translational and clinical research, pharmaceutical development, commercialization of innovations, and graduate and postgraduate education. The quality and effectiveness of the training program will be assessed by an independent assessor. The intended outcome of this program is to train the next generation of leaders in translational neuroscience who have the knowhow and passion to take basic discoveries to clinical trials and treatments that benefit millions with neurological diseases.