Pilot/Exploratory Studies Core

试点/探索性研究核心(PESC)：项目摘要 飞行员/探索性研究核心(PESC)的总体目标是培养和支持尖端飞行员 和探索性研究，将促进对脆弱的有效预防和/或治疗的发展 从而促进老年人的独立。PESC核心领导者与其他人密切合作 核心领导者，为脆弱研究的下一阶段设定科学目标，然后努力确定 调查人员的专业知识和职业目标将适用于进一步加深我们在 有针对性的区域。这些领导者寻找可以收集所需数据的先导性和探索性研究 为了选择或设计建立脆弱机制所需的未来大规模或验证性研究， 确定病因，或开发新的治疗和筛查方法。获选资助的研究 这个周期的第一年包括一项研究，该研究试验了一种同时解决疼痛的行为干预方法 和老年非裔美国女性的脆弱，一项新陈代谢研究试图确定脆弱与 通过C13标记的葡萄糖耐量试验研究能量失调的代谢物特征 寻求通过识别睡眠障碍和虚弱之间的联系来进一步理解 特定的多导睡眠图特征，使用功能数据分析，并探索潜在的 周期性关系。PESC的具体目标是：1)促进脆弱的科学和翻译 通过提供必要的智力领导进行研究，以确定研究的目标领域和 最能实现本OAIC翻译目标的调查人员，2)支持开发 设计良好且内容翔实的试点研究，3)为受支持人员提供和进行纵向指导 通过完成试点奖励和为下一阶段研究争取资金，调查人员，4) 进一步指导试点研究成果的转化；5)拓展研究环境， 关注脆弱性的调查人员网络需要实现OAIC的总体目标。这些目标将是 与生物统计学、生物机制和临床转化和 招聘核心领导人，以确保最佳设计和获得研究成功所需的核心资源。 这一核心的重要发现可以通过新的信息传播广泛传播 本申请中提出的核心(IDC)。这一核心将指导试点工作向更深层次转化 了解脆弱性的基本生物学和种群影响，并将其转化为将 预防或治疗脆弱，从而有助于保持独立性。

Pilot / Exploratory Studies Core (PESC): Project Summary The overall goal of the Pilot / Exploratory Studies Core (PESC) is to cultivate and support cutting edge pilot and exploratory studies that will advance the development of effective prevention and/or therapies for frailty and hence facilitate independence in older adults. The PESC Core leader, in close collaboration with other core leaders, set scientific goals for the next stages of frailty research, and then work to identify investigators whose expertise and career goals would be applicable to furthering our knowledge in the targeted areas. These leaders search for pilot and exploratory studies that can collect data required in order to select or design the future large-scale or confirmatory studies needed to establish frailty mechanisms, determine etiologies, or develop novel treatment and screening approaches. Studies selected for funding in the first year of this cycle include a study that pilots a behavioral intervention to concurrently address pain and frailty in older African American women, a metabolomic study that seeks to identify frailty-related metabolite signatures of energy dysregulation through a C 13 labeled glucose tolerance test, and study that seeks to further understanding of the connection between sleep disturbance and frailty by identifying specific polysomnographic signatures implicated, using functional data analysis, and exploring a potential cyclical relationship. The specific aims of the PESC are to 1) advance the science and translation of frailty research by providing intellectual leadership necessary to identify targeted areas of research and investigators that can best accomplish the translational goals of this OAIC, 2) to support the development of well-designed and informative pilot studies, 3) to provide and conduct longitudinal mentorship to supported investigators through completion of the pilot award and pursuit of funding for the next stage of research, 4) to further guide the translation of any pilot study results, and 5) to expand the research environment and network of frailty-focused investigators needed to accomplish the overall OAIC goals. These aims will be carried out in close collaboration with biostatistics, biological mechanisms, and clinical translational and recruitment core leaders to ensure optimal design and access to core resources needed for study success. Important findings from this core can be broadly disseminated through the new Information Dissemination Core (IDC) proposed in this application. This core will guide the translation of pilot work into a deeper understanding of the basic biology and population implications of frailty and into interventions that will prevent or treat frailty hence help maintain independence.