Training Program in Lung Biology and Translational Medicine

摘要 亚拉巴马大学肺生物学和转化医学培训项目 伯明翰（UAB）提供多学科培训，在一个刺激和协作的环境，培养 培养高度胜任和创新的生物医学研究科学家。该计划于2004年启动， 2010年，培养医学博士。或博士肺相关研究的博士后研究员，目前已进入第10个年头， 每年分配6名受训人员。在该方案的头10年，16/17（94%）完成了培训的学员 继续在研究密集型职业轨道上进行培训，14/17人（>80%）担任学术教师职位。 对拟议的培训采取的多学科和转化方法非常成功， 由30名教师导师组成的多元化互动小组突出强调，他们在八个国家/地区担任主要职务。 UAB部门（4 -临床; 4 -研究）。教师导师分为三个主题领域的基础上 关于科学专门知识：（1）免疫学-微生物学;（2）细胞生物学-组织修复;（3）转化科学。 统计遗传学、计算生物学、生物标志物发现和药物的转化研究 发现/开发和临床试验将促进基础科学研究的临床转化（第1组 和2）。根据UAB现有的专业知识和正在进行的研究工作，培训将侧重于 肺部疾病的表现、诊断、风险/预后分层、机制、预防和治疗， 主要是急性肺损伤（ALI）、囊性纤维化（CF）、哮喘、慢性阻塞性肺疾病（COPD），以及 间质性肺疾病（ILD）。培训计划将高度个性化和量身定制，以最大限度地提高成功率 通过制定个人发展计划（IDPs），为每一位受训者提供培训。除了研究项目， 将在导师的实验室进行，培训将包括一个高度结构化的教学计划， 包括每周在肺，过敏和重症监护医学部教学会议，一个“生存” 技能”课程（与博士后教育UAB办公室合作）和研究核心 课程，由T32培训教师进行，其中包括新兴的主题，如细胞可塑性， 人类免疫学、干细胞生物学、衰老、药物发现/开发、生物信息学和个性化 药正式的指导将包括负责任和道德的研究行为和严格的课程 和研究的可重复性。这个T32培训计划致力于“导师的指导”，劳动力 多样性，并保持目前高比例的学员保留在学术生物医学研究的职业生涯。

ABSTRACT The Training Program in Lung Biology and Translational Medicine at the University of Alabama at Birmingham (UAB) provides multidisciplinary training in a stimulating and collaborative environment that nurtures the development of highly competent and innovative biomedical research scientists. This Program, initiated in 2010 to train M.D. or Ph.D. postdoctoral fellows in lung-related research, is currently in its 10th year with a current allocation of 6 trainees/year. In the first 10 years of the Program, 16/17 (94%) of trainees who have completed training have continued in research-intensive career tracks, and 14/17 (>80%) hold academic faculty positions. The multidisciplinary and translational approach to the proposed training has been highly successful, and is highlighted by a diverse and interactive group of thirty faculty mentors who hold primary appointments in eight UAB Departments (4 – clinical; 4 – research). The faculty mentors are grouped into three thematic areas based on scientific expertise: (1) immunology-microbiology; (2) cell biology-tissue repair; (3) translational sciences. Translational research in statistical genetics, computational biology, biomarker discovery, and drug discovery/development and clinical trials will facilitate the clinical translation of basic science research (groups 1 and 2). Based on the existing expertise and ongoing research efforts at UAB, training will focus on the manifestations, diagnosis, risk/prognostic stratification, mechanisms, prevention, and treatment of lung diseases, primarily acute lung injury (ALI), cystic fibrosis (CF), asthma, chronic obstructive lung diseases (COPD), and interstitial lung diseases (ILD). Training programs will be highly individualized and tailored to maximize success of each trainee with the creation of individual development plans (IDPs). In addition to the research projects that will be conducted in the mentor’s laboratory, training will encompass a highly structured didactic program that includes weekly teaching conferences in the Division of Pulmonary, Allergy and Critical Care Medicine, a “survival skills” curriculum (in collaboration with the UAB Office of Postdoctoral Education) and a Research Core Curriculum, conducted by the T32 training faculty, that includes emerging themes such as cellular plasticity, human immunology, stem cell biology, aging, drug discovery/development, bioinformatics, and personalized medicine. Formal instruction will include the responsible and ethical conduct of research and a course on rigor and reproducibility in research. This T32 Training Program is committed to “mentoring of mentors”, workforce diversity, and maintaining the current high-rate of trainee retention in academic biomedical research careers.