RC-ISC

ISC摘要/摘要：集成系统核心(ISC)的基本概念是 与年龄相关的灵活性和平衡性改变在明显的临床问题之前会发生微妙的变化，并归因于 多系统互动变化。ISC提供与年龄相关的最先进的多学科专业知识 通过协作实验室改变移动性，包括1)全身运动和平衡，2) 神经系统结构、功能和能量学，以及3)心肺和肌肉骨骼结构， 机能和能量学。这些实验室相互合作，以及与其他Pepper核心合作 和中心为研究研究带来同步的多系统评估。在当前周期中， ISC支持了11个试探性研究(PES)、2个发展项目(DPS)、23名REC学员(7名 学者)，以及50多个外部资助项目(EP)，几乎所有这些项目都涉及与其他国家的合作 胡椒中心、其他皮特中心、其他胡椒中心和其他机构。 在此次续订中，ISC将与其他Pepper核心合作，支持3个PES和2个DPS。ISC 将为以下方面增加广泛和创新的新资源：1)体内线粒体的非侵入性评估 心、脑和肌肉的功能；2)运动时的心肺生理变化；3)肌肉 结构、神经和能量学，包括脊髓生理学；4)一套经过验证的任务，详细说明 评估双重任务和认知-运动接口；以及5)可穿戴设备测量大脑和 步行时的肌肉活动(近红外和高密度肌电)，以及通过组合的就地空间导航 加速度计--实验室外的GPS系统。我们的具体目标是： 1.提供前沿资源和专业知识，同时研究全身和多个 影响衰老过程中活动和平衡的系统和生理机制，两者都在研究中 规划以及在执行和分析期间也是如此。 2.开发和测试新的技术和方法，以解决多系统的差距和需求 机动性和平衡性的评估。 3.通过教育和支持胡椒学员的工作，支持OAIC的培训使命 通过工作组、研讨会、“实地考察”和积极参与学员研究项目。 4.与皮特内外的其他核心和中心合作开展与伊斯兰会议组织有关的活动。 5.在核心内部和核心之间持续监测、评估和沟通核心活动 实验室领导以及其他Pepper核心、Pepper Leadance和NIA。 总之，ISC自匹兹堡胡椒成立以来一直是匹兹堡胡椒的核心 有助于创造和传播预防和治疗衰老的新知识和新方法-- 与机动性和平衡性相关的问题。

ISC Summary/Abstract: The fundamental concepts underlying the Integrative Systems Core (ISC) are that age-related alterations in mobility and balance develop subtly, prior to overt clinical problems, and are due to multi-system interacting changes. The ISC provides state-of-the-art multidisciplinary expertise on age-related change in mobility via collaborating laboratories encompassing 1) whole-body movement and balance, 2) nervous system structure, function and energetics, and 3) cardiopulmonary and musculoskeletal structure, function and energetics. These laboratories collaborate with each other, as well as with other Pepper Cores and Centers to bring simultaneous multisystem evaluation to research studies. During the current cycle, the ISC supported 11 pilot exploratory studies (PES), 2 developmental projects (DPs), 23 REC trainees (7 scholars), and over 50 externally funded projects (EP), virtually all of which involved collaboration with other Pepper Cores, other Pitt Centers, other Pepper Centers, and other institutions. In this renewal, the ISC will support 3 PES and 2 DPs in collaboration with other Pepper Cores. The ISC will add extensive and innovative new resources for: 1) non-invasive in-vivo assessment of mitochondrial function in heart, brain and muscle; 2) cardio-pulmonary physiological changes during exercise; 3) muscle structure, innervation and energetics including spinal cord physiology; 4) a validated set of tasks for detailed assessment of dual tasks and the cognitive-motor interface; and 5) wearable devices to measure cerebral and muscle activity while walking (NIRS and high-density EMG), as well as in-place spatial navigation via combined accelerometry-GPS systems outside the laboratory. Our specific aims are: 1. Provide cutting-edge resources and expertise to concurrently study both whole-body as well as multiple systems and physiologic mechanisms affecting mobility and balance during aging, both during study planning as well as during implementation and analysis. 2. Develop and test novel techniques and approaches to address gaps and needs for multi-system evaluation of mobility and balance. 3. Support the training mission of the OAIC by educating and supporting the work of Pepper trainees through workgroups, seminars, “field trips” and active involvement in trainee research projects. 4. Collaborate with other Cores and Centers in and outside Pitt on OAIC-related activities. 5. Continuously monitor, evaluate and communicate about Core activities both within and among Core laboratory leaders, as well as with other Pepper Cores, Pepper leadership and NIA. In summary, the ISC has formed the heart of the Pittsburgh Pepper since its inception and has been instrumental in creating and disseminating new knowledge and new approaches to prevent and treat age- related problems with mobility and balance.