Force-Based Manipulations Research Network

摘要 虽然存在大量的机械感觉知识，但我们目前对机械感觉的理解 跨学科的感觉机械转导和基于力的操作(FBM)机制 仍然受到严格的限制。事实证明，这些研究领域之间缺乏协同是一个可怕的问题 FBM进展和治疗优化的障碍。加快跨学科协作 研究和推进FBM领域，我们的目标是建立一个全国性/国际化的学术和专业 基于力的操纵网络(FORCEnet)。FORCEnet的任务将是成功地克服 长期存在的障碍涉及：1)缺乏与FBM力相关的通用指标；2)缺乏FBM 机械知识(包括机械敏感感受器、神经元和回路在病理过程中如何变化 条件)，以及3)上下文因素对FBM机制的未定义但潜在的重要作用。至 为了实现我们的网络目标，我们将促进生理学、 生物力学、大数据/人工智能、神经科学、免疫学、成像和心理学强调 临床和翻译相关的研究解决了FBM施加力的度量，神经机制 FBM机械转导和FBM上下文效应。FORCEnet将重点发展新的 跨学科协作和提交新的试验性和转化性临床前试验 项目。这些试点项目将包括基本的理论框架和翻译设计，主要 和二次分析，新的和辅助的项目，并将向整个学术领域的研究人员开放 职业范围。FORCEnet的目标是扩大和多样化FBM员工队伍，开发新的FBM渠道 跨学科研究人员，并鼓励更大的研究密集型公众之间的新合作 大学和规模较小的综合医学机构。FORCEnet将使用各种途径来创建和 分享新的FBM知识和资源，包括执行FBM Delphi研究，在 《手法和手法治疗杂志》的特刊，主持面对面和虚拟的研讨会， 网络研讨会，创建一个互动网站，FORCEnet成员可以在其中定位未来的跨学科 合作者，并使用社交媒体来推广和共享网络资源。飞行员资助奖获得者将出席 他们在我们的年度FORCEnet研讨会上的研究成果，旨在鼓励新的跨学科FBM 合作。为了在资助期结束后保持FORCEnet网络的增长，我们将建立FORCEnet 年大型国家/国际科学会议上的“特殊利益集团”、卫星活动和社会活动 FORCEnet成员定期出席和/或担任领导职务。作为目前该领域的领导者 基础和临床FBM研究，提供给FORCEnet领导团队的资源以及我们的 高度可见的机构和建立的跨学科合作者个人网络提出了我们的建议 处于有利地位，将在未来几十年对FBM机械研究和临床护理产生重大影响。

ABSTRACT Whereas a large body of mechanosensation knowledge exists, synergy between our current understanding of sensory mechanotransduction and Force-Based Manipulations (FBM) mechanisms across research disciplines remains severely limited. This lack of synergy between these research fields has proven to be a formidable barrier to the advancement and therapeutic optimization of FBM. To accelerate interdisciplinary collaborative research and advance the FBM field, we aim to establish a national/international academic and professional Force-Based Manipulation network (ForceNet). The charge of ForceNet will be to successfully overcome the long-established barriers pertaining to: 1) the lack of universal FBM force-related metrics, 2) the lack of FBM mechanistic knowledge (including how mechanosensitive receptors, neurons, and circuits change in pathological conditions), and 3) the undefined but potentially important role of contextual factors on FBM mechanisms. To accomplish our Network goals, we will stimulate interdisciplinary research at the intersections of physiology, biomechanics, big data/artificial intelligence, neuroscience, immunology, imaging and psychology emphasizing clinical and translationally relevant research addressing FBM metrics of applied force, neural mechanisms of FBM mechanotransduction, and FBM contextual effects. ForceNet will emphasize the development of new interdisciplinary collaborations and the submission of novel experimental and translational pre-clinical pilot projects. These pilot projects will encompass basic, theoretical framework, and translational designs, primary and secondary analyses, new and ancillary projects, and will be open to investigators across the entire academic career spectrum. ForceNet aims to grow and diversify the FBM workforce, develop a pipeline of new FBM interdisciplinary investigators, and encourage new collaborations between larger research-intensive public universities and smaller Integrative Medicine institutions. ForceNet will use a variety of avenues to create and share new FBM knowledge and resources including performing a FBM Delphi Study, publishing 6-10 articles in a special issue of Journal of Manual and Manipulative Therapy, hosting face-to-face and virtual, workshops, webinars, creating an interactive website where ForceNet members can locate future interdisciplinary collaborators, and using social media to promote and share Network resources. Pilot grant awardees will present their research findings at our annual ForceNet workshops, designed to encourage new interdisciplinary FBM collaborations. To sustain ForceNet network growth after the funding period ends, we will establish ForceNet “special interest groups”, satellite events, and social events at large national/international scientific meetings in which ForceNet members attend regularly and/or serve in a leadership capacity. As current leaders in the field of basic and clinical FBM research, the resources provided to the ForceNet Leadership Team along with our highly visible institutions and established personal networks of interdisciplinary collaborators makes our proposal well positioned to substantially impact FBM mechanistic research and clinical care for decades to come.