Core B: Clinical Translational Core

项目摘要：临床翻译核心(CTC) HAWK-IDDRC的临床翻译核心(CTC)旨在解决这些人面临的挑战 通过为研究人员提供资源，将发现从 将实验室应用于临床实践，并使您能够了解作为临床观察基础的生物学， 以促进翻译研究。反恐委员会通过为招聘提供基础设施而脱颖而出 农村人口以及生命周期中关键过渡点的参与者，包括：围产期 时期，青春期和青春期，不同程度独立的成年期，以及后来的成年期 专业护理员担当主要角色。这些过渡点代表着影响 IDD患者的长期福祉，然而我们对每一种疾病的了解都是有限的。重要的是，农村 人口1)获得适当护理的机会减少，2)有不同的潜在IDD暴露， 研究不到位；3)缺乏研究基础。HAWK-IDDRC CTC准备满足这些需求，并 因此将提供从这一未被研究的人群中获取独特的临床数据和生物样本的途径 制定了以下目标：1)促进和加快IDD患者的招募和临床评估 来自不同领域的所有生命阶段的患者将他们和他们的家人与临床研究和 资源；2)为IDD研究人员提供生物库和生物信息学服务；3)促进和支持 通过为临床提供成功的架构来设计、开发和测试新的IDD疗法 为IDD研究人员提供试验和药物制造服务。反恐委员会的专门知识和资源- 导演(Mark Santillan和Alexander Bassuk)涵盖了广泛的能力，包括 产前风险评估，到人类受试者招募，以及临床数据和生物样本的存储。特定的 爱荷华大学(UI)覆盖寿命的资产包括CoLab(全球怀孕协作)、 一个由40个站点组成的国际合作，专注于妊娠结局研究，共享临床数据和 生物样本；Spark的临床招募中心，一项全国性的自闭症基因研究；UI领导的全州范围内 农村和城市地区的合作诊所、学校和提供者网络；以及智障- 精神病(ID-MI)诊所，全国仅有的几个专注于患有精神疾病的患者的住院单位之一 智力残疾和同时发生的精神疾病。反恐委员会将作为以下方面的中心协调中心 资源，简化调查人员的访问，并使其能够支持31个联邦资助的项目 每年总计1260万美元。访问统一、协调的临床数据、生物样本和 临床队列允许CTC与所有核心合作，进行回顾性和前瞻性的IDD研究。 反恐委员会的资源将支持HAWK-IDDRC的任务，以提供组织结构 将基础和临床研究整合到整个生命周期--从受孕到成年--专注于 预防、诊断、治疗和改善IDDS，并为服务不足的农村人口量身定做。

PROJECT SUMMARY: CLINICAL TRANSLATIONAL CORE (CTC) The Clinical Translational Core (CTC) of the Hawk-IDDRC seeks to address the challenges faced by those living with IDD at all life stages by providing investigators the resources to transition discoveries from the laboratory into clinical practice, and enable an understanding of the biology underlying clinical observations, in order to advance translational research. The CTC differentiates itself by providing infrastructure for recruiting rural populations as well as participants at key transition points across the lifespan, including: the perinatal period, puberty and adolescence, adulthood at varying levels of independence, and later adulthood as professional caregivers assume a primary role. These transition points represent critical periods that influence the long-term wellbeing of those living with IDD, yet our understanding of each is limited. Importantly, rural populations 1) have decreased access to appropriate care, 2) have different potential IDD exposures that are not well studied, and 3) lack research infrastructure. The Hawk-IDDRC CTC is poised to fill these needs and will thus provide access to unique clinical data and biosamples from this understudied population by carrying out the following aims: 1) Facilitate and accelerate the recruitment and clinical evaluation of IDD-affected patients at all stages of life and from diverse areas to connect them and their families with clinical studies and resources; 2) Provide IDD researchers with biobanking and bioinformatics services; 3) Facilitate and support the design, development, and testing of novel IDD therapies by providing a successful architecture for clinical trials and drug manufacturing services to IDD researchers. The expertise and resources of the CTC Co- Directors (Mark Santillan and Alexander Bassuk) covers a broad spectrum of capabilities, ranging from prenatal risk assessment, to human subject recruitment, and banking of clinical data and biosamples. Specific assets of the University of Iowa (UI) that cover the lifespan include CoLab (Global Pregnancy Collaboration), an international collaboration of 40 sites focused on pregnancy outcome research, sharing clinical data and biosamples; a clinical recruitment center for SPARK, a nationwide genetic study of autism; UI-led statewide networks of collaborating clinics, schools, and providers in rural and urban areas; and the Intellectual Disability- Mental Illness (ID-MI) clinic, one of only a handful of inpatient units in the country that focuses on patients with intellectual disability and a co-occurring mental illness. The CTC will serve as a central focal point for these resources, streamlining access for investigators, and enabling its support of 31 federally funded projects totaling $12.6 million per year. The access to a unified, harmonized source of clinical data, biosamples, and clinical cohorts allows the CTC to work with all Cores to perform retrospective and prospective IDD studies. The resources of the CTC will support the mission of the Hawk-IDDRC to provide an organizational structure that integrates basic and clinical research across the lifespan—from conception to adulthood—focused on the prevention, diagnosis, treatment and amelioration of IDDs, and tailored to a rural, underserved population.