BEHAVIORAL PHENOTYPING CORE

项目摘要/抽象行为表型核心 行为表型核心(BPC)支持开发、实施和传播 广泛的科学调查集中在了解影响大脑发育的机制上， 智力和发育障碍(IDD)患者的行为和认知。独特的核心 属性包括：(1)通过以下方式获取有关广泛遗传和神经发育障碍的数据 登记和研究数据库，其中包括27,000多名神经认知/行为表型较深的个人； (2)在评估和干预功能非常低下的个人方面拥有丰富的专业知识，包括 有感觉、运动和/或沟通障碍的人，以及有最严重和最具挑战性的 行为；(3)能够通过可穿戴设备和基于视频的评估实施远程评估 技术；(4)500多项有效的定量神经心理和行为评估目录 准备好通过训练有素的检查员在临床试验中实施的仪器；(5)最先进的动议 配备运动成像、机器人、力分析、感觉和本体感觉的分析单元 测量能力；和(6)临床和研究神经生理学资源，包括全方位 可通过脑电和多导睡眠图进行测量。这些独特的核心功能允许 研究人员调查IDD的所有生物标记物(神经成像、生理学、“组学”)，并将 这些都直接影响到人类的深层行为表型。 具体目标主要是通过将核心教员专业知识与资源相结合来实现的。 来自核心内部四个互补单位的设施、设备和直接服务，包括行为 分析、运动分析、发展神经心理学和临床神经生理学。有了这些富有和 提供多样化的资源，开发和验证临床试验准备情况的各种结果衡量标准 在IDD中，是核心的基本组成部分，与传播或资源和科学 发现。

PROJECT SUMMARY/ABSTRACT – BEHAVIORAL PHENOTYPING CORE The Behavioral Phenotyping Core (BPC) supports development, implementation, and dissemination of a broad spectrum of scientific inquiries focused on understanding mechanisms affecting brain development, behavior, and cognition among individuals with intellectual and developmental disabilities (IDD). Unique Core attributes include: (1) access to data about a wide range of genetic and neurodevelopmental disorders, via a registry and research database of over 27,000 individuals with deep neurocognitive/behavioral phenotyping; (2) significant expertise in assessment and intervention with very low functioning individuals, including those with sensory, motor, and/or communication impairments, and individuals with the most severe and challenging behaviors; (3) ability to implement remote assessments through wearable and video-based assessment technology; (4) a catalog of over 500 validated quantitative neuropsychological and behavioral assessment instruments, ready to implement in clinical trials via highly- trained examiners; (5) a state-of-the-art motion analysis unit equipped with movement imaging, robotics, force analysis, sensation and proprioception measurement capabilities; and (6) clinical and research neurophysiology resources, including a full range measurements available through EEG and polysomnography. These unique Core features allow for researchers to investigate the full range of biomarkers (neuroimaging, physiologic, “-omic”) in IDD, and to link these directly to deep behavioral phenotyping in humans. Specific aims are accomplished primarily through the integration of Core faculty expertise with resources, facilities, equipment, and direct services from four complementary units within the Core, including behavior analysis, motion analysis, developmental neuropsychology and clinical neurophysiology. With these rich and diverse resources, development and validation of a wide range of outcome measures for clinical trial readiness in IDD, is a fundamental component of the Core, along with dissemination or resources and scientific discoveries.