Engineering Core C

项目摘要/摘要--工程核心(核心C) 该计划将包括一个工程核心(核心C)，由Michael R.Bailey博士和R.Lee共同领导 汤普森博士，在应用物理实验室(APL)传感器阵列制造实验室工作。 目前还没有现成的硬件来执行超声波推进(UP)或冲击波碎石术(BWL)。这 仪器设备都是定制的，需要特定的专业知识来制造驱动电子设备和传感器 能够安全可靠地产生所需的输出。这些传感器产生的输出不同于 典型的高强度聚焦超声(HIFU)换能器和冲击波碎石机 驱动电子设备以产生合适的脉冲类型。开发传统HIFU设备和 碎石机对UP或BWL设备的设计限制几乎没有或根本没有经验。在商业上没有单一的 可用的系统或传感器可以产生参数调查所需的大范围输出 在项目2中执行，因此必须制造和校准几个类似的传感器。核心C是为数不多的 拥有制造成像和治疗超声系统的专业知识和经验的国际设施 用于工业和研究，因此，它在支持本计划项目赠款方面是独一无二的。 核心C将为超声换能器和 供我们的研究团队使用的控制/电力电子设备。核心C的总体目标是确保所有 实验是用适当的、经过校准的、准确的仪器进行的。为了实现这一目标， 核心C有三个具体目标。目标1是为这三家公司生产和维护相同的硬件系统 项目。这项工作确保项目拥有正确的工具来执行他们的研究。目标2是为了证明 并为所有三个项目维护UP和BWL硬件的校准。这项工作确立了一种品质 FDA可接受的控制框架，以获得严格和可重复的结果。目标3是设计新硬件 为三个项目中的每个项目产生特定应用所需的所需输出和配置。AS 研究进展，我们希望确定具体的产出或产出的组合，以提高石头 特定的(S模式)超声成像、BWL和UP应用。这些增强功能可能会带来新的 对传感器或电子设备所需输出范围的要求。因此，为了实现 拟议的项目旨在，核心C将设计和制造新的换能器或电子设备，并执行 输出的固件和软件编码，以及跨输出的同步以满足项目要求 要求。

PROJECT SUMMARY/ABSTRACT - Engineering Core (Core C) The Program will include an Engineering Core (Core C) co-led by Michael R. Bailey, Ph.D. and R. Lee Thompson Ph.D. and housed in the Applied Physics Laboratory (APL) Transducer Array Fabrication Laboratory. There is no off-the-shelf hardware to perform ultrasonic propulsion (UP) or burst wave lithotripsy (BWL). This instrumentation is all custom built and requires specific expertise to create driving electronics and transducers capable of safely and reliably generating the required outputs. These transducers produce outputs different from typical high intensity focused ultrasound (HIFU) transducers and shock wave lithotripters and require specific drive electronics to produce appropriate pulse types. Companies who develop traditional HIFU devices and lithotripters have little or no experience with the design constraints of UP or BWL devices. No single commercially available system or transducer can produce the large range of outputs desired for the parametric investigation performed in Project 2, so several similar transducers must be made and calibrated. Core C is one of a handful of facilities internationally with expertise and experience in fabricating imaging and therapy ultrasound systems for industry and research, and thus, is unique in its ability to support this Program Project Grant. Core C will provide design, fabrication, and characterization support for the ultrasound transducers and control/power electronics to be used by our research teams. The overall goal of Core C is to ensure that all experiments are conducted with appropriate, calibrated, and accurate instrumentation. To accomplish that goal, Core C has three specific aims. Aim 1 is to produce and maintain identical hardware systems across for all three Projects. This work ensures that the Projects have the correct tools to perform their studies. Aim 2 is to certify and maintain calibration of the UP and BWL hardware for all three Projects. This work establishes a quality control framework acceptable to FDA for rigorous and reproducible results. Aim 3 is to engineer new hardware to produce desired outputs and configurations needed for specific applications by each of the three Projects. As research progresses, we expect to determine specific outputs or combinations of outputs that will enhance stone specific (S-mode) ultrasound imaging, BWL, and UP applications. These enhancements may impose new requirements on the range of outputs needed from a transducer or electronics. As such, in order to accomplish the proposed Project Aims, Core C will design and fabricate new transducers or electronics, and perform firmware and software coding of the outputs, and synchronization across outputs to meet the project requirements.