West Nile virus control through mosquitocidal avian bloodmeals

项目摘要 西尼罗河病毒(West Nile Virus，WNV)是一种蚊媒黄病毒，是引起国内获得性虫媒病毒的主要原因 美国的疾病，每年在人类和其他人中导致重大疾病和死亡 动物。迫切需要有效的、针对媒介的干预措施，但目前的媒介控制方法 (主要是喷洒到环境中的杀虫剂)不足以控制西尼罗河病毒。我们一直在 开发和测试含有杀虫剂处理的禽类饲料的站，作为控制西尼罗河病毒的一种方式 在西尼罗河病毒病发病率最高的美国西部地区向人类传播 在北美，通过瞄准主要的桥梁媒介蚊子，塔尔萨利库蚊。该项目旨在 开发经杀虫药物处理的禽类饲料作为一种新的、安全的和经科学验证的方法来控制 西尼罗河病毒在美国西部向人类传播的概念是，鸟类将通过 包含经过处理的饲料的鸟饲站，这些饲料将作为阵列放置在房主的财产上，在 社区或公园里。然后，经过处理的鸟类的血液将杀死西尼罗河的主要蚊子媒介 以血液为食的病毒，这将降低西尼罗河病毒传播给活着的人的风险， 在喂鸟站周围工作和娱乐。

Project Summary West Nile virus (WNV) is a mosquito-borne flavivirus, and the leading cause of domestically-acquired arboviral disease in the United States, resulting in significant disease and death every year among humans and other animals. Efficacious, vector-targeted interventions are critically needed, but current vector control methods (primarily insecticides sprayed into the environment) have been inadequate for WNV control. We have been developing and testing stations that contain endectocide-treated bird feed as a way to control WNV transmission to humans in the western U.S., the region which suffers from the highest incidence WNV disease in North America, by targeting the primary bridge vector mosquito, Culex tarsalis. This project is designed to develop endectocide-treated birdfeed as a novel, safe and scientifically-validated way to control the risk of West Nile virus transmission to humans in the western U.S. The concept is that birds will self-medicate by birdfeed stations containing the treated feed, which would be placed as arrays on homeowners' properties, in neighborhoods or in parks. The blood of treated birds would then kill the primary mosquito vectors of West Nile virus that blood feed on them, which would lower the risk of West Nile virus transmission to people who live, work and recreate around the birdfeed stations.