Core B - Training Core

项目摘要/摘要MDSRC培训核心的总体目标是增加训练有素、有科学能力的研究人员数量，能够维持肌肉营养不良的生产性基础科学、翻译和/或临床研究计划。为了实现这一中心目标，该中心将确定和招聘合格的基础科学和临床博士后和博士后候选人，这些候选人对肌营养不良症的独立基础科学、翻译和/或临床研究表现出真正的兴趣和潜力。将特别重视从种族、族裔、性别、社会经济地位和残疾人数不足的群体中招聘受训人员。培训核心和相关配套资金将在任何时候支持MDSRC教师实验室的至少三名博士后实习生，以及至少一名博士后实习生和一名临床实习生。加州大学和加州大学洛杉矶分校的培训中心将监督和协调由核心和匹配基金支持的受训人员的一系列培训活动，以及在MDSRC项目支持的研究人员的实验室中从事肌肉营养不良研究的博士后、博士后和临床同事。每个学员将根据他们过去的培训以及他们的主要导师和论文委员会的建议，准备一份个人发展计划。根据受训者的职业阶段，个性化计划可能包括结构化的教学计划、研讨会和有指导的补助金撰写经验。所有博士前实习生将被要求在各自的机构注册涵盖肌肉健康和疾病、撰写论文和负责任地进行研究的课程。临床研究实习生将进一步被要求参加与临床试验的设计和实施有关的课程。加州大学和加州大学洛杉矶分校都开设了关于肌营养不良症的具体课程--肌肉营养不良症和肌病，以及加州大学洛杉矶分校的肌营养不良症的机制和治疗。加州大学洛杉矶分校的课程完全在线，可供加州大学系统内外的任何学生使用，UF课程录制将于2021年春季完成，并向三个网站的学员提供。培训中心将通过以下方式进一步改善培训环境：1)支持每年在密歇根大学和加州大学洛杉矶分校举办的研讨会；2)前往参加NCH/OSU肌学年度课程，以及为参加该课程的学员，为来自密歇根大学、加州大学洛杉矶分校和北卡罗来纳大学的学员举办一个见习报告之夜；3)前往威斯通中心出席我们的肌肉生物学和疾病新方向(New Directions)国际会议。此外，MDSRC中心将继续举办两个以肌肉健康和疾病为重点的国际会议--新方向会议和骨骼肌生物学在健康和疾病中的进展会议。在新方向会议上，培训核心将为不同韦尔斯通中心的学员举办一次学员数据闪电战，以促进互动和数据共享。

Project Summary/Abstract The overall objective of the MDSRC Training Core is to increase the number of rigorously trained and scientifically competent researchers capable of sustaining productive basic science, translational and/or clinical research programs in muscular dystrophy. To meet this central objective, the core will identify and recruit qualified basic science and clinical predoctoral and postdoctoral candidates who demonstrate a genuine interest in, and potential for, independent basic science, translational and/or clinical research in muscular dystrophy. Particular emphasis will be placed on the recruitment of trainees from underrepresented groups with respect to race, ethnicity, gender, socio-economic status and disabilities. The Training Core and associated matching funds will support at least three predoctoral trainees in MDSRC faculty labs at any one time, plus at least one postdoctoral trainee and one clinical trainee. The Training Cores at UF and UCLA will oversee and coordinate a spectrum of training activities for trainees supported by the core and matching funds, as well as the predoctoral, postdoctoral and clinical fellow researchers engaged in muscular dystrophy research in the labs of researchers supported through the projects of the MDSRC. Each trainee will prepare an Individual Development Plan, based on their past training and recommendations from their primary mentor and thesis committee. Depending on the career stage of the trainee, the individualized plan may consist of a structured didactic program, seminars, and mentored grant writing experiences. All predoctoral trainees will be required to enroll in courses at their respective institutions that cover muscle health and disease, grant writing and responsible conduct of research. Trainees in clinical research will further be required to enroll in courses related to the design and conduct of clinical trials. Both UF and UCLA offer specific courses on muscular dystrophies - Muscular Dystrophy and Myopathies at UF and Mechanisms and Therapies for Muscular Dystrophies at UCLA. The UCLA course is fully online and available to any student across the University of California system and beyond, and the UF course recording will be complete in Spring 2021, and made available to trainees across the three sites. The Training Cores will further enhance the training environment by supporting 1) annual trainee hosted seminars at UF and UCLA, 2) travel to attend the Annual NCH/OSU Myology Course and, for those attending the course, a trainee presentation evening for trainees from UF, UCLA and NU and, 3) travel to present at our Wellstone Center aligned New Directions in Muscle Biology and Disease (New Directions) international conference. In addition, the MDSRC Center will continue to organize two international conferences focused on muscle health and disease – the New Directions Conference, and Advances in Skeletal Muscle Biology in Health & Disease Conference. At the New Directions Conference, the Training Core will host a Trainee Data Blitz for trainees across the different Wellstone Centers to facilitate interactions and data sharing.