FASEB SRC: Structure and Function of Small GTPases

总结 合理的癌症药物设计需要彻底了解信号网络，以揭示节点 可以被瞄准。小GTP酶是许多信号通路的中心组分，包括许多 驱动肿瘤发生和转移的基因。小型GTP是二进制交换机， 通过受体和调节分子将GDP结合关闭到GTP结合开启状态，并且当处于开启状态时， 通过各种效应分子驱动信号。小GTP酶的超家族数量超过160个 基因产物，可分为五个家族：RAS，RHO，RAB，ARF和RAN蛋白。RAS蛋白 是第一个被鉴定的小GTP酶，并且仍然是最好的研究。RAS基因是癌基因， 在癌症中的突变频率比其他任何一种都高，这就引起了人们对理解和 针对这些GTP酶FASEB小型GTP酶夏季研究会议成立于1991年 此后每两年举行一次。会议一直吸引着该领域的领导者， 在推动该领域向前发展和促进加速发现的合作方面发挥了重要作用 已经转化为药物发现。会议还作为一个平台， 年轻的研究人员进入该领域。此申请旨在为30周年纪念会议寻求部分资金 关于小GTP酶的结构和功能的FASEB SRC。会议将以主题演讲为特色 Channing Der是会议的联合创始人之一，他仍然是该领域的推动力。也精选 将举行28次全体会议。50%的受邀演讲者是会议的新成员， 新的想法和技术。将从提交的摘要中选出20个简短的演讲，并由 年轻的科学家所有与会者将提交海报。非正式讨论和建立联系的机会 将在为期5天的会议上大量出现，其中包括下午的计划外时间，以及 专家午餐和职业发展早餐。43%的受邀演讲者是女性。一 计划作出协调一致的努力，招聘代表性不足群体的学员。十 将向受训人员颁发旅行/登记奖，优先考虑代表人数不足的少数群体。

Summary Rational drug design for cancer requires a thorough understanding of signaling networks in order to reveal nodes that can be targeted. Small GTPases are central components of numerous signaling pathway, including many that drive oncogenesis and metastasis. Small GTPases are binary switches that are interconverted from the GDP-bound off to the GTP-bound on state by receptors and regulatory molecules and, when in the on state, drive signaling through various effector molecules. The superfamily of small GTPases number more than 160 gene products and can be divided into five families: RAS, RHO, RAB, ARF and RAN proteins. RAS proteins were the first small GTPases identified and remain the best studied. RAS genes are the oncogenes more frequently mutated in cancer than any other, which accounts for the intense interest in understanding and targeting these GTPases. The FASEB Summer Research Conference on Small GTPases was founded in 1991 and has been held every two years since. The conference has consistently attracted the leaders in the field and has played a large role in driving the field forward and promoting collaborations that have expedited discoveries that have been translated into drug discovery. The conference has also served as a platform for encouraging young investigators to enter the field. This application seeks partial funding for the 30th Anniversary Meeting of the FASEB SRC on the Structure and Function of Small GTPases. The meeting will feature a keynote lecture by Channing Der, one of the co-founders of the meeting who remains a driving force in the field. Also featured will be 28 plenary talks. Fifty percent of the invited speakers are new to the conference and are intended to bring fresh ideas and technologies. Twenty short talks will be selected from submitted abstracts and delivered by young scientists. All attendees will present posters. Opportunities for informal discussions and for networking will abound over the 5-day meeting that will include unscheduled time in the afternoons as well as a Meet-the- Expert lunch and a Career Development breakfast. Forty-three percent of invited speakers are woman. A concerted effort is planned to recruit trainees who are members of underrepresented groups. Ten travel/registration awards will be made to trainees with preference given to underrepresented minorities.