2022 Mutagenesis Gordon Research Conference and Gordon Research Seminar

项目摘要/摘要 2022年戈登突变研究会议将探讨尖端研究 所有生物基因组序列变化的机制和后果 生命的分支。生物体基因蓝图的改变是许多问题的核心 生物学和病理学方面。尽管这是一个久负盛名的会议，但《突变》 仍然是一个前沿话题，跨越了许多领域的传统界限。它推动着进化 癌症，细菌逃脱抗生素的杀戮以及有益的过程，如 作为病毒限制和有效的适应性免疫。重要的是，常见的分子机制 将这些明显不同的进程联系起来，会议的一个主要目标将是将 通常不会强烈交互的场。此外，会议将强调广泛的 从深度测序到单分子生物物理的实验方法 所有职业阶段和背景的科学家，从学术界到工业界。GRC将 包括28位受邀演讲者，24个演讲时段，从摘要中选择以及 一个互动的海报会议。此外，在主会议之前的GRS将有 专门为研究生和博士后提供的更多口头和海报演示机会， 以及一个职业小组讨论会。主会议上的“权力一小时”将集中在 女性在科学领域面临的挑战。我们的目标是营造一个互动、友好的环境 思想可以自由交流，而不受背景或资历的限制。为此， 会议和工作餐将辅之以积极的社会计划，以促进 这些互动。GRC课程将安排为上午九点和晚上九点 题为：(1)诱变的基本机制(主旨会议)；(2)DNA 复制叉处的损伤耐受性；(3)突变机制的可视化；(4)突变 由复制错误引起；(5)依赖RNA的突变；(6)重复和屏障诱导 突变；(7)了解癌症和衰老中的突变特征；(8)环境 和内源诱变；(9)进化和适应。因此，GRC和GRS将 促进在诱变和驱动的广泛领域中的最新思想和技术的交流 新想法和跨领域合作，同时促进和促进下一代的职业生涯 一代科学家在这个充满活力和令人兴奋的领域。

Project Summary / Abstract The 2022 Gordon Research Conference on Mutagenesis will explore cutting edge research into the mechanisms and consequences of changes in the genomic sequence of organisms from all branches of life. Alterations to the genetic blueprint of an organisms lies at the heart of many aspects of biology and pathology. Despite being a well-established conference, `Mutagenesis' remains a forefront topic, bridging the traditional boundaries of many fields. It drives the evolution of cancer, the escape of bacteria from killing by antibiotics as well as beneficial processes such as viral restriction and effective adaptive immunity. Importantly, common molecular mechanisms link these apparently diverse processes and a key aim of the conference will be to bring together fields that do not normally interact strongly. Further, the meeting will highlight a wide range of experimental approaches from deep sequencing to single molecule biophysics and bring together scientists of all career stages and backgrounds, from academia to industry. The GRC will comprise 28 invited speakers with 24 slots for talks to be selected from the abstracts as well as an interactive poster session. In addition, the GRS, which precedes the main conference will have further oral and poster presentation opportunities specifically for graduate students and post-docs, as well as a career panel discussion. A `power hour' in the main meeting will focus on the challenges facing women in science. We aim to foster an interactive, friendly environment in which ideas can be freely exchanged independently of background or seniority. To that end, the sessions and working meals will be supplemented with a vigorous social program to foster these interactions. The GRC program will be organized into nine morning and evening sessions entitled: (1) Fundamental mechanisms of mutagenesis (Keynote session); (2) DNA damage tolerance at the replication fork; (3) Visualizing mutagenic mechanisms; (4) Mutagenesis arising from replication errors; (5) RNA-dependent mutagenesis; (6) Repeat and barrier-induced mutagenesis; (7) Understanding mutagenic signatures in cancer and aging; (8) Environmental and endogenous mutagenesis and (9) Evolvability and adaptation. The GRC and GRS will thus promote exchange of the latest ideas and techniques in the broad field of mutagenesis and drive new ideas and cross-field collaborations while enhancing and promoting the careers of the next generation of scientists in this dynamic and exciting field.