Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)

摘要/项目摘要--总体构成部分 患有儿童风湿和非炎症性肌肉骨骼疾病(PMSKD)的儿童有一个紧急的 需要循证医疗，考虑到儿童和成人之间的显著差异 人口。为了解决科学知识方面的这些差距，我们建议建立一种儿科肌肉骨骼 位于辛辛那提儿童医院医疗中心的风湿病创新核心中心(PORTICO)。 Portico的目标将是促进地方和国家对PMSKD的有影响力的研究，重点是 我们在青少年关节炎、狼疮和青少年纤维肌痛方面的成熟研究计划。具体目标是： 目标1：以先进的数据科学、数据分析促进创新并支持临床研究 能力和数据管道开发。 目标2：振兴地方和全国研究人员社区的跨学科团队科学 PMSKD。 目标3：通过开发和提供尖端评估工具来加强对PMSKD的研究 健康干预和描绘PMSKD表型的益处。要支持的高级映像服务 PMSKD研究(超声波、磁共振成像、生物力学评估)将 提供了新的基于成像的方法和评分系统，并提供了一个交互式仪表板 从患者报告的评估、成像数据、新型生物标志物和传统的 为支持改进的共享医疗决策而制定的疾病措施。 预期结果：Portico将创造一个充满活力的研究环境，培养富有成效的团队科学 寻找有关PMKSD的重要科学未知数的答案。创新将通过(1)发展 PMSKD的诊断(实验室测试、成像测试)，并测试它们与临床护理的集成；以及(2) 推进循证治疗，重点是JIA、CSLE和JFM。Portico调查结果的传播 而地方和国家研究社区的增加将通过多站点研究实现， Portico的外联计划及其试点和可行性研究计划。与其他公司的努力保持一致 CCCRs、参与PMSKD研究的其他组织以及当地研究环境预计将 促进Portico调查人员传播思想和创新

ABSTRACT/PROJECT SUMMARY - OVERALL COMPONENT Children with pediatric rheumatic and non-inflammatory musculoskeletal diseases (PMSKD) have an urgent need for evidence-based medical care that considers the striking differences between pediatric and adult populations. To address these gaps in scientific knowledge, we propose to establish a Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO) at the Cincinnati Children' Hospital Medical Center. Objectives of PORTICO will be to promote impactful research in PMSKD, locally and nationally, with a focus on our well-established research programs in juvenile arthritis, lupus and juvenile fibromyalgia. Specific Aims are: Aim 1: To promote innovation and support clinical research with advanced data science, data analytics capabilities, and data pipeline development. Aim 2: To invigorate cross-disciplinary team science of the local but also national community of researchers in PMSKD. Aim 3: To enhance research in PMSKD by developing and offering cutting-edge assessment tools for capturing the benefits of health interventions and delineating PMSKD phenotypes. Advanced imaging services to support PMSKD research (ultrasonography, magnetic resonance imaging, biomechanical assessment) will be provided, new imaging-based methods and scoring systems developed and an interactive dashboards to synthesize information from patient reported assessments, imaging data, novel biomarkers and traditional disease measures developed in support of improved shared medical decision making. Expected result: PORTICO will create a vibrant research environment that fosters productive team science to find answers to important scientific unknowns regarding PMKSD. Innovation will be sought by (1) developing diagnostics for PMSKD (laboratory tests, imaging tests) and testing their integration into clinical care, and (2) advancing evidence-based based therapies, with focus on JIA, cSLE and JFM. Spread of PORTICO findings and increase of the local & national Research Community will be achieved by multisite research studies, PORTICO's Outreach Program, and its Pilot & Feasibility Studies Program. Alignment with the efforts of other CCCRs, other organizations involved in PMSKD research, and the local research environment is anticipated to potentiate spread of ideas and innovation by PORTICO investigators