Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Core

生物医学信息学、生物信息学和网络基础设施 增强核心 临床和转化研究的成功执行依赖于协调的访问，策展， 管理、保存、分析和传播来自多个来源的数据、信息和知识 (e.g.,学术、健康和政府）。Advance-CTR生物医学信息学的长期目标， 生物信息学和网络基础设施增强（BIBCE）的核心是改变临床环境 和转化研究在罗得岛，使访问电子健康数据，提供核心 信息基础设施，并确定传播，实施和改进战略， 克服在实践中采用证据的障碍。核心活动由布朗中心协调， 生物医学信息学，沿着来自Advance-CTR合作伙伴（布朗大学， 罗得岛、Lifespan、Care新英格兰、弗吉尼亚州普罗维登斯医疗保健系统、罗得岛部 和罗得岛质量研究所）。通过与我们的数据合作伙伴的正式安排，我们 克服访问和共享全州数据的障碍。BIBCE核心下一阶段的重点将是 建立可扩展的资源和服务，以实现标准化和综合接入。定期接触 来自学术界、卫生界和政府界的主要利益相关者的参与， 进一步加强资源和服务，以促进可持续发展。核心还寻求培训和参与 研究人员在应用资源，知识和技能，以支持数据和技术的最佳做法， 在基础，临床和人口科学的范围内推动项目。BIBCE核心的使命是 从而促进数据和技术的使用，以支持临床和转化研究的全方位。 具体目标是：（1）促进可持续和可扩展的信息基础设施，以支持 临床和转化研究需求的多样性;（2）开发创新数据，软件和技术 与临床和翻译研究人员合作提供解决方案;以及（3）提供最先进的信息学 与临床和转化研究利益相关者的培训和接触。BIBCE核心利用了 罗得岛的多样化人口，以传播，实施和改进与我们的 地方社区，并在全国范围内推广。为成功改造和振兴临床和 转化研究与生物医学信息学定义的国家评估标准保持一致 社区RE-AIM（Reach，Effectiveness，Adoption，Implementation，and Maintenance） 框架，并与跟踪和评估核心合作，我们将评估这些成果，影响， 和衡量在满足总体Advance-CTR目标方面的进展和成功的指标，包括我们州的 卫生优先事项。Advance-CTR合作伙伴的持续参与， 改善国家和地区人口健康的技术将协同扩大临床和 转化研究机会。

ABSTRACT – BIOMEDICAL INFORMATICS, BIOINFORMATICS, AND CYBERINFRASTRUCTURE ENHANCEMENT CORE The successful execution of clinical and translational research relies on coordinated access, curation, management, preservation, analysis, and dissemination of data, information, and knowledge from many sources (e.g., academic, health, and government). The long-term goal of the Advance-CTR Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement (BIBCE) Core is to transform the environment for clinical and translational research in Rhode Island by enabling access to electronic health data, providing core informatics infrastructure, and identifying dissemination, implementation, and improvement strategies to overcome barriers to adoption of evidence into practice. Core activities are coordinated by the Brown Center for Biomedical Informatics, along with leadership from Advance-CTR partners (Brown University, The University of Rhode Island, Lifespan, Care New England, VA Providence Healthcare System, the Rhode Island Department of Health, and the Rhode Island Quality Institute). Through formal arrangements with our data partners, we have overcome barriers to accessing and sharing statewide data. The focus of the next phase of the BIBCE Core will be on establishing scalable resources and services for standardized and integrated access. Regular engagement of key stakeholders from the academic, health, and government communities has been critical as BIBCE Core resources and services are further enhanced to promote sustainability. The Core also seeks to train and engage researchers in best practices for applying resources, knowledge, and skills to support data- and technology- driven projects across the spectrum of basic, clinical, and population science. The mission of the BIBCE Core is thus to advance use of data and technology to support the full spectrum of clinical and translational research. The Specific Aims are to: (1) Promote a sustainable and extensible informatics infrastructure to support the diversity of clinical and translational research needs; (2) Develop innovative data, software, and technology solutions in collaboration with clinical and translational researchers; and, (3) Provide state-of-the-art informatics training and engagement with clinical and translational research stakeholders. The BIBCE Core capitalizes on the diverse population of Rhode Island to disseminate, implement, and improve solutions that are relevant to our local community, and still be scaled nationally. Metrics for success to transform and invigorate clinical and translational research are aligned with national standards for evaluation as defined by the biomedical informatics community. Guided by the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework and in collaboration with the Tracking and Evaluation Core, we will evaluate these outcomes, impacts, and metrics to gauge progress and success in meeting overall Advance-CTR objectives, including for our state’s health priorities. The continued engagement of Advance-CTR partners with the shared vision of using data and technology to improve the health of the State’s and regional population will synergistically expand clinical and translational research opportunities.