Promoting High-Impact Alzheimer's Disease Research through the Use of Statewide Registries: Expanding Diversity in Aging Research.

项目总结/摘要 建立机制，增加从事衰老和阿尔茨海默氏症研究的科学家的渠道 疾病和相关痴呆症（ADRD），并指导这些科学家，是国家公共卫生的优先事项。这是 国家老龄化研究所（NIA）以及疾病控制中心的长期目标证明了这一点， 预防（疾病预防控制中心）和阿尔茨海默氏症协会“国家和地方公共卫生伙伴关系，以解决痴呆症： 2018-2023年路线图”。拟议项目通过设立一个年度 会议题为“通过使用全州登记册促进高影响阿尔茨海默病研究： 扩大老龄化研究的多样性。该系列会议还讨论了NIA的ADRD实施里程碑 4.S：“改进和增加培训，包括对代表性不足人口的个人的培训， 研究AD/ADRD健康差异的学者的不同职业水平。” 系列会议的具体目标是：1.为代表性不足的少数群体和非代表性群体提供一个论坛， URM研究人员学习如何使用全州注册表进行高影响力的ADRD研究; 2：提供 高级教师/专家通过提交资料指导初级URM研究人员进行AD登记研究的机制 a）在下一年的R13会议上提交的摘要，和B）同行评审的手稿 3：提供一种机制，支持统一资源管理机制和非统一资源管理机制研究人员之间正在进行的联网; 4： 对项目进行过程和结果评估，并根据需要进行修改。 拟议的会议系列利用了MPIs在为URM和非URM提供指导方面的成功领导。 URM教师和本科生通过几个积极的NIA支持机制，包括阿尔茨海默氏症- 卡罗莱纳老年痴呆症和少数族裔中心 研究（CCADMR）; MPI Levkoff & Friedman，研究教育组件负责人Ingram），南卡罗来纳州- 推进老龄化研究的多样性（SC-ADAR; PI Levkoff）计划，以及CDC的健康大脑研究网络（PI Friedman）。类似于我们的国家情报局资助的项目，会议系列将扩大我们的全州合作， 克莱姆森大学和南卡罗来纳州医科大学（MUSC），以及三所历史上的黑人学院， 大学（HBCUs）-克拉夫林大学、艾伦大学和南卡罗来纳州州立大学。更多伙伴 包括美国（US）唯一活跃的全州AD注册中心，位于西弗吉尼亚州的格鲁吉亚，以及 南卡罗来纳州（最后一个是设在一个办公室，是共同指导的MPI弗里德曼）。国家投资管理局供资的额外资金 合作伙伴包括隶属于加州大学洛杉矶分校RCMAR协调中心、南加州大学的研究人员 (USC)AD-RCMAR和USC/UCLA生物人口学和人口健康中心。系列会议将 有助于我们的最终目标多样化的研究队伍在老龄化和ADRD和推进科学 ADRD差异。

PROJECT SUMMARY/ABSTRACT Establishing mechanisms for increasing the pipeline of scientists who conduct research in aging and Alzheimer’s disease and related dementias (ADRD), and mentoring these scientists, are national public health priorities. This is evidenced in the long-term goals of the National Institute on Aging (NIA), as well as Centers for Disease Control and Prevention (CDC), and Alzheimer’s Association “State and Local Public Health Partnerships to Address Dementia: The 2018-2023 Road Map”. The proposed project responds to these priorities through the establishment of an annual conference entitled, “Promoting High-Impact Alzheimer’s Disease Research through the Use of Statewide Registries: Expanding Diversity in Aging Research.” This conference series also addresses the NIA’s ADRD Implementation Milestone 4.S: “To improve and increase training, including for individuals who are members of under-represented populations, and of different career levels of scholars who conduct health disparities research in AD/ADRD.” The specific aims of the conference series are to: 1: Provide a forum for underrepresented minority (URM) and non- URM researchers to learn how to conduct high-impact ADRD research using statewide registries; 2: Provide a mechanism for senior faculty/experts to mentor junior URM researchers in AD registry research through the submission of a) an abstract for presentation at the following year’s R13 conference, and b) a manuscript to a peer-reviewed journal; 3: Provide a mechanism to support ongoing networking among URM and non-URM researchers; and 4: Conduct process and outcome evaluations of the program, making modifications as needed. The proposed conference series leverages the MPIs’ successful leadership in providing mentoring to URM and non- URM faculty and undergraduate students through several active NIA-supported mechanisms, including the Alzheimer’s- related Resource Centers for Minority Aging Research (RCMAR; Carolina Center on Alzheimer’s Disease and Minority Research (CCADMR); MPIs Levkoff & Friedman, Research Education Component Lead Ingram), the South Carolina- Advancing Diversity in Aging Research (SC-ADAR; PI Levkoff) program, and the CDC’s Healthy Brain Research Network (PI Friedman). Similar to our NIA-funded projects, the conference series will extend our statewide collaborations with Clemson University and the Medical University of South Carolina (MUSC), and three Historically Black Colleges and Universities (HBCUs) - Claflin University, Allen University, and South Carolina State University. Additional partners include the only active statewide AD registries in the United States (US), which are located in Georgia, West Virginia, and South Carolina (the last of which is housed within an office that is co-directed by MPI Friedman). Additional NIA-funded partners include researchers affiliated with the UCLA RCMAR Coordinating Center, University of Southern California (USC) AD-RCMAR, and USC/UCLA Center on Biodemography and Population Health. The conference series will contribute to our ultimate goal of diversifying the research workforce in aging and ADRD and advancing the science on ADRD disparities.