Core 3 Non Human Primate Studies

辐射对抗研究卓越中心 核心3：灵长类研究 摘要 灵长类研究核心促进开展晚期临床前缓解剂研究 非人灵长类动物的辐射损伤(NHP)，遵循RadCCORE的特定优先事项 并与全国其他CMCR共享组织和数据。因为高度的 非人灵长类与人类在遗传和生理上的相似性，这一资源是至关重要的 试验性环境中的候选交付代理的翻译评估的组成部分 在这种情况下，健康受试者可以接受相应剂量的全身照射。堆芯 研究人员在非人类灵长类动物的实验使用和临床医学方面拥有独特的技能， 包括辐射、兽医护理和骨髓抑制动物的管理， 灵长类比较病理学、辐射损伤病理学、生物化学、临床病理学和 灵长类的内分泌学，以及分子生物学技术对灵长类模型的适应。堆芯 服务包括研究计划、监管批准、获取和维护特定的- 无病原体的非人类灵长类动物对辐射的暴露，治疗性给药 干预措施以及对治疗结果的临床和病理评估，包括 尸检/组织收集和共享，以确定辐射反应和 对减轻干预措施的评估。核心还提供广泛的数据管理服务 用于灵长类研究，包括数据共享和与生物统计核心的互动，以促进分析 并公布调查结果。拟议供资期间的主要核心用户将是项目3，FSL-1 作为胃肠道和造血缓解剂，但所有项目都将通过共享组织、液体 和数据；设计和审查未来前瞻性研究的计划。

Radiation Countermeasures Center of Research Excellence Core 3: Primate Studies Abstract The Primate Studies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates (NHP), following the specific priorities of the RadCCORE consortium and sharing tissue and data with other CMCRs nationwide. Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational assessment of candidate deliverable agents, in an experimental setting under which relevant doses of whole-body irradiation can be given to healthy subjects. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates, including irradiation, veterinary medical care and management of myelosuppressed animals, comparative pathology of primates, pathology of radiation injury, biochemistry, clinical pathology and endocrinology of primates, and adaptation of molecular biologic techniques to the primate model. Core services include study planning, regulatory approvals, acquisition and maintenance of specific- pathogen-free nonhuman primates, exposure of animals to radiation, administration of therapeutic interventions, and clinical and pathologic assessments of treatment outcomes, including necropsy/tissue collection and sharing for baseline characterization of radiation responses and assessment of mitigating interventions. The Core also provides extensive data management services for primate studies, including data sharing and interaction with the biostatistics core to facilitate analysis and publication of findings. The main core user for the proposed funding period will be Project 3, FSL-1 as a GI and hematopoietic mitigator, but all Projects will be served, through sharing of tissues, fluids and data; design and review of plans for future prospective studies.