Aspen Lung Conference: Bridging the Gap between Innate and Adaptive Immunity in the Lung

项目摘要/摘要 强调基础、翻译和临床方法的整合，第64届阿斯彭肺展 会议将集中讨论一个中心问题：如何了解 肺部疾病加深了我们对疾病发展的理解，并转化为 治疗肺部疾病的有效方法？为了解决这一核心问题，该计划被组织成 一系列专题会议，由最先进的演讲者框定主题。专题会议将集中讨论 论(I)单核巨噬细胞先天免疫的作用及其在炎症性肺病中的作用 在肺中弥合先天免疫反应和获得性免疫反应之间的差距，专注于宿主微生物 相互作用，(Iii)评估先天性免疫反应和获得性免疫反应之间的界面在COVID和其他 肺疾病，(Iv)获得性免疫在自身免疫和自身免疫性肺发育中的作用 (5)了解从免疫癌症治疗和方法中吸取的经验教训；和(6) 确定未来的治疗选择，以利用免疫系统产生新的。通过解决这些问题 主题，我们寻求实现以下目标：1)为领先的基础、翻译和 临床研究人员就免疫系统在疾病发生和发展中的作用交换意见 慢性肺部疾病的进展；2)促进科学领域之间的互动，以确定新出现的和 共同的兴趣可能导致更有效率和更有成效的研究；3)增加成功的可能性 通过开发新的战略，将临床前科学进步转化为患者的直接利益，以更好地 了解疾病的发病机制，并在治疗慢性肺部疾病方面取得科学进展；以及 4)挑战和激发学员的科学兴趣，吸引新一代初级调查人员 进入肺部的先天免疫和适应性免疫领域。我们已经确定了12位杰出的思想领袖 关于这些主题的当前艺术状态讲座(35分钟)。每次演讲后将有25分钟的 讨论--本会议的一个标志。该计划延续了阿斯本肺脏会议致力于 多样性和包容性：N=6/13(54%)最先进的演讲者/总结者是女性，我们的 发言者来自代表性不足的种族/民族群体。促进受训人员和初级教员的参与 通过两个15分钟的口头摘要，从提交的摘要中挑选出来，紧跟在每个技术现状演讲者之后(24 总计)。将有两个晚上的海报会议，供初级教员和 实习生。最终演示文稿由会议总结者提供，他回顾了会议的影响和共同 会议的主题。会议纪要将出版广泛分发，为 作为一个“智囊团”，它不仅总结了该领域的现状，而且还确定了未来的关键方向 用于基础、翻译和临床研究。最后，值得注意的是，阿斯彭肺脏会议的注册人数是 免费的，鼓励广泛的实习生和早期职业调查人员的参与。

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational, and clinical approaches, the 64th annual Aspen Lung Conference will focus on a central question: how can knowledge of the immunologic mechanisms that underlie lung disease enhance our understanding of disease development and be translated into effective approaches to treat lung disease? To address this central question, the program is organized into a series of thematic sessions, with State of the Art speakers framing the topic. The thematic sessions will focus on (i) the role of innate immunity via mononuclear phagocytes and its impact on inflammatory lung disease, (ii) bridging the gap between the innate and adaptive immune responses in the lung focusing on the host-microbe interactions, (iii) evaluating the interface between the innate and adaptive immune response in COVID and other lung diseases, (iv) the role of adaptive immunity in the development of autoimmunity and autoimmune lung disease, (v) understanding lessons learned from immunologic cancer treatments and approaches, and (vi) defining future treatment options to harness the immune system for generation of novel. By addressing these topics, we seek to accomplish the following: 1) provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding the role of the immune system in the development and progression of chronic lung disease; 2) stimulate interactions between scientific fields to identify emerging and shared interests that may lead to more efficient and productive research; 3) enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better understand disease pathogenesis and implement scientific advances in treatment of chronic lung diseases; and 4) challenge and stimulate the scientific interests of trainees and attract a new generation of junior investigators into the field of innate and adaptive immunity in the lung. We have identified 12 outstanding thought leaders to present State of the Art lectures (35 min) on these topics. Each presentation will be followed by 25 minutes of discussion - a hallmark of the Conference. The program continues the Aspen Lung Conference’s dedication to diversity and inclusivity: n=6/13 (54%) of State of the Art speakers/Summarizer are women, and at least 6 of our speakers are from underrepresented racial/ethnic groups. Participation of trainees and junior faculty is facilitated by two 15-minute oral abstracts, selected from submitted abstracts, following each State of the Art speaker (24 total). There will be two evening poster sessions for further presentation opportunities by junior faculty and trainees. The final presentation is provided by a Conference Summarizer, who reviews the impact and common themes of the Conference. The Conference Summary will be published for widespread dissemination, to serve as a “think tank” that not only summarizes the current state of the field, but also identifies key future directions for basic, translation, and clinical research. Finally, and notably, registration for the Aspen Lung Conference is free, encouraging participation from a wide spectrum of trainees and early career investigators.