Project 2

摘要研究项目2 研究2被整合到转型中心，以促进下一代的研究， 虐待儿童问题，将研究结果转化为临床和预防干预措施，以及传播 研究和实践知识/技能，以不同的利益相关者。这项研究是由一个发展的 精神病理学的角度，结合生命周期框架内的多层次分析。孩子 虐待往往对各种心理和生理造成严重的不良后果， 对身心健康有长期有害影响的发展过程中的系统。 因此，增加对虐待儿童影响健康和福祉的机制的了解， 制定和推进有效的干预措施，具有至关重要的公共卫生意义。项目2评估了 儿童虐待对成年人身心健康的长期后果，通过纵向跟踪， 在儿童期最初评估的个体在成年期增加。后续将包括随机- 从现有的较大样本中选出600名年龄在21-44岁之间的人。在学龄期间， 这些成年人参加了在Mt.希望家庭中心，并全面衡量各种 获得了自出生以来虐待的各个方面，对虐待问题进行了更深入的报道 成人回顾性自我报告。对儿童的多领域、多信息提供者的衡量 适应/适应不良功能进行了评估，包括皮质醇调节的儿童措施，提供 这是一个难得的机会来评估成年人身心健康的长期预测模型。成年后 将从参与者那里获得一套全面的措施。除了目前的生活状况，我们 将评估累积的生活压力和创伤史，以及个人适应资源，即，自 效能感、自尊、情绪调节、人格。皮质醇调节将通过头发样本获得 和家庭唾液样本将获得人体测量和心脏测量以及多个 通过血液样本评估生物标志物和免疫功能。抽血也将提供DNA， 确定目标基因型和表观遗传修饰。最后，身心健康将是 通过结构化访谈和问卷调查进行评估。分析将评估儿童的长期后果 虐待累积压力，个人资源，非稳态负荷，表观遗传修饰，和身体 和心理健康结果。我们还将评估儿童早期适应的发展质量 皮质醇调节可能介导成人的结果，这些调节的遗传和表观遗传调节 调解过程。这项工作将为下一代儿童的进步奠定基础。 对虐待问题的研究以及对新的预防和干预目标的深入了解。

ABSTRACT RESEARCH PROJECT 2 Research Study 2 is integrated into the TRANSFORM Center to promote the next generation of research on child maltreatment, translation of research findings into clinical and preventive interventions, and dissemination of research and practice knowledge/skills to varied stakeholders. The research is informed by a developmental psychopathology perspective, incorporating multiple levels of analysis within a lifespan framework. Child maltreatment frequently results in serious adverse consequences to diverse psychological and biological systems in the course of development that have long-term detrimental effects on physical and mental health. Thus, increasing knowledge of the mechanisms through which child maltreatment impacts health and well- being, and advancing effective interventions, are of crucial public health significance. Project 2 evaluates the long-term consequences of child maltreatment on adult physical and mental health through longitudinal follow- up of individuals initially assessed in childhood during adulthood. The follow-up will include a randomly- selected sample of 600 individuals aged 21-44 years from a larger existing sample. During school-age years, these adults participated in research at Mt. Hope Family Center, and comprehensive measurements of diverse aspects of maltreatment since birth were obtained, providing a more in-depth coverage of maltreatment experiences than adult retrospective self-report. Multi-domain, multi-informant measurements of childhood adaptive/maladaptive functioning were assessed, including childhood measures of cortisol regulation, providing a rare opportunity to evaluate models of long-term predictors of adult mental and physical health. In adulthood a comprehensive battery of measures from participants will be obtained. In addition to current life status, we will assess cumulative life stress and history of trauma, as well as personal adaptive resources, i.e., self- efficacy, self-esteem, emotion regulation, personality. Cortisol regulation will be obtained through hair samples and in-home saliva samples. Anthropometric and cardiac measurements will be obtained as well as multiple biomarkers and immune functions assessed via blood samples. Blood draws will also provide DNA to determine targeted genotypes and epigenetic modifications. Finally, physical and mental health will be assessed by structured interviews and questionnaires. Analyses will evaluate long-term consequences of child maltreatment on cumulative stress, personal resources, allostatic load, epigenetic modifications, and physical and mental health outcomes. We also will evaluate developmentally how earlier quality of childhood adaptation and cortisol regulation may mediate adult outcomes, and genetic and epigenetic moderation of these mediational processes. This work will provide the foundation for the next generation of advances in child maltreatment research and insight into new prevention and intervention targets.