The Oklahoma Pediatric Clinical Trials Network

项目总结/摘要 俄克拉荷马州儿科临床试验网络（OPCTN）的目标是为 俄克拉荷马州服务不足的农村、城市少数民族和美洲印第安儿童人口 临床试验和转让有益于这些儿童健康的发现。OPCTN将继续 成为环境对儿童健康结果的影响（ECHO）的成员 临床试验网络（ISPCTN）。ISPCTN促进了IDEA州的研究中心参与设计和 实施与5个主要ECHO重点领域相关的临床试验：1）上气道和下气道疾病，2） 肥胖; 3）产前、产后和产后结果; 4）神经发育;和5）积极的儿童健康。这些是 俄克拉荷马州的每个重大健康问题领域，我们的整体儿童健康被评为 在美国最差。 OPCTN的第一阶段成功地发展了儿科临床试验的能力， 指导初级临床研究者，建立临床信息学资源，领导ISPCTN 网络和参与ISPCTN领导的试验。OPCTN一直是前三大招聘网站之一 在该网络内，领导了一项以农村人口为重点的ISPCTN可行性试验。 对于OPCTN的这一更新阶段，我们在俄克拉荷马州内汇集了各种各样的资源。 它集中在儿科系和俄克拉荷马州临床和转化科学研究所， 俄克拉荷马州大学健康科学中心。它结合了俄克拉荷马州的IDEA-CTR的资源， 俄克拉荷马州共享临床和转化资源，学术医师在国家的对抗疗法医疗 学校，斯蒂芬森癌症中心的临床试验专家，俄克拉荷马州城乡的供应商 社区和基于实践的研究网络，以扩大儿童在 俄克拉荷马州参加临床研究。OPCTN与社区顾问团体合作 代表美国印第安人、拉丁美洲人和非洲裔美国人社区以及县级卫生机构的机构 国家内的改进组织，允许他们对研究项目的设计，实施， 社区参与感。OPCTN还侧重于培训儿科临床医生和研究人员， 增强他们在设计和开展临床试验方面的经验，以提高 医学界在国家进行临床和转化研究的努力。

PROJECT SUMMARY/ABSTRACT The goal of the Oklahoma Pediatric Clinical Trials Network (OPCTN) is to provide access for the underserved rural, urban minority, and American Indian populations of children in Oklahoma to state-of-the-art clinical trials and the transfer of findings that will benefit the health of those children. The OPCTN will continue to be a member of the Environmental influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ISPCTN). The ISPCTN facilitates involvement of sites in IDeA states to design and implement clinical trials related to the 5 primary ECHO focus areas: 1) upper and lower airway disease, 2) obesity; 3) pre-, peri-, and postnatal outcomes; 4) neurodevelopment; and 5) positive child health. These are each areas of substantial health concern for Oklahoma, where our overall child health is rated amongst the worst in the United States. The first phase of OPCTN was successful in developing capacity for pediatric clinical trials through mentoring of junior clinical investigators, building clinical informatics resources, leadership with the ISPCTN network, and participation ISPCTN-led trials. The OPCTN was consistently among the top three recruiting sites within the network and led the development of an ISPCTN feasibility trial focused on rural populations. For this renewal phase of the OPCTN, we have assembled a diverse mixture of resources within Oklahoma. It is centered in the Department of Pediatrics and the Oklahoma Clinical and Translational Science Institute at the University of Oklahoma Health Sciences Center. It combines the resources of Oklahoma’s IDeA-CTR, the Oklahoma Shared Clinical and Translational Resources, academic physicians at the state’s allopathic medical school, clinical trials experts at the Stephenson Cancer Center, providers in Oklahoma urban and rural communities, and practice-based research networks in order to broaden the opportunities for children in Oklahoma to participate in clinical research studies. The OPCTN engages with community consultant groups that represent the American Indian, Latino, and African American communities as well as county-based health improvement organizations within the state to allow their input on research project design, implementation, and community participatory interest. The OPCTN also focuses on training pediatric clinicians and research staff to enhance their experience in the design and conduct of clinical trials in order to increase the capacity of the medical community in the state to conduct clinical and translational research efforts.