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中文摘要
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项目概要:动物服务核心 动物服务中心的结构是为了满足研究人员对转化研究不断变化的需求 通过提供资源来开发眼部疾病的实验动物模型并测试递送, 新治疗药物的疗效。其目标是:1)提供专家援助和监督, 转基因和基因敲除/敲入动物群体的管理,包括其基因分型; 2) 提供动物设施和设备的使用,提供使用指导,并监督 进行动物手术和组织采集; 3)提供开发设备, 产生眼部疾病和病理性眼部病症的动物模型; 4)在以下方面提供帮助: 活体动物成像; 5)作为研究人员和大学动物设施之间的联络人, 服务
英文摘要
PROJECT SUMMARY: ANIMAL SERVICES CORE The Animal Services Core is structured to meet the evolving needs of investigators for translational research by providing resources to develop experimental animal models of ocular diseases and test the delivery and efficacy of new therapeutic agents. The goals are: 1) to provide expert assistance and oversight in the management of transgenic and gene knockout/knockin animal colonies, including their genotyping; 2) to make available the use of animal facilities and equipment, provide guidance in their utilization, and supervise the performance of animal procedures and tissue harvesting; 3) to make available equipment for development and generation of animal models of ocular diseases and pathologic eye conditions; 4) to provide assistance in imaging of live animals; 5) to serve as a liaison between investigators and the University's animal facilities and services.
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Functional tomography of neurovascular coupling interactions in healthy and diseased retinas
Functional tomography of neurovascular coupling interactions in healthy and diseased retinas
Super-resolution ophthalmoscopy for in vivo retinal imaging
Functional imaging of retinal photoreceptors
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