MOLECULAR ONCOLOGY TRAINING GRANT

摘要 分子肿瘤学是一个快速变化的领域，在我们对肿瘤的理解方面有了显着的新进展。 肿瘤细胞的基本生物学及其与微环境的相互作用。这导致了越来越多的 批准的新肿瘤药物数量，其中大多数针对信号传导的特定成分 途径。基础癌症生物学家的现代培训需要广泛的技能和知识， 学科这是华盛顿大学分子的第二次竞争性更新申请 肿瘤学培训计划，自2006年以来一直由NCI的T32奖资助。它提供 1名博士前和4名博士后科学家的津贴，目前的申请要求为 下一阶段的培训人数相同。这些资金已经并将继续得到补充， Siteman癌症中心，为另外6名博士前科学家提供津贴。每个学员 参加该计划两年。到目前为止，该计划已培养了66名博士生和22名 博士后研究员，几乎所有人都继续从事科学研究。资金 仅限于具有博士学位或获得博士学位的学员，不包括具有MD或MD-PhD或其他 学位，或目前在这样的研究生课程。因此，目前的方案填补了一个关键和重要的 这一机构的教育作用，不与其他培训计划重叠。该计划包括34 教师在许多不同的部门谁拥有大量的研究资金和经验， 指导学生和研究员，他们专注于了解实体瘤的分子基础， 造血系统恶性肿瘤发生和进展。学员参加年度教学课程 每年春季和秋季学期的期刊俱乐部，年度务虚会和研究进展会议 年内学员还参加临床和转化科学指导计划之一 秋季学期的每个月。目前的新应用是生物信息学靴子训练营， 午餐研讨会系列成像和药物发现，以及赠款写作计划，重点是具体的 我们癌症中心的服务区的需求

ABSTRACT Molecular Oncology is a rapidly changing field, with remarkable new advances in our understanding of the basic biology of tumor cells and their interaction with the microenvironment. This has led to an increasing number of new oncology drug approvals, with the majority targeting specific components of signaling pathways. Modern training for basic cancer biologists requires diverse skills and knowledge in a wide range of disciplines. This is the second competitive renewal application of the Washington University Molecular Oncology Training Program, which has been funded by a T32 award from the NCI since 2006. It provides stipends for 1 predoctoral and 4 postdoctoral scientists, and the current application requests funds for the same number of trainees in the next period. This funding has been, and will continue to be supplemented by the Siteman Cancer Center, which provides stipends for 6 additional predoctoral scientists. Each trainee participates in the program for 2 years. Thus far, the program has trained 66 predoctoral students and 22 postdoctoral fellows, almost all of whom have continued their careers in scientific research. Funding is restricted to trainees with a PhD or those obtaining a PhD, and excludes those with MDs or MD-PhD or other degrees, or currently in such graduate programs. Thus, this current program fills a critical and important educational role for this institution that does not overlap with other training programs. The program includes 34 faculty members in many different departments who have substantial research funding and experience in mentoring students and fellows, who are focused on understanding the molecular basis of solid tumor and hematopoietic malignancy development and progression. Trainees participate in an annual didactic course each spring and journal clubs each fall semester, an annual retreat, and research-in-progress meetings throughout the year. Trainees also participate in a Clinical and Translational Science Mentoring Program one day each month in the fall semester. New in the current application are a bioinformatics boot camp, and luncheon seminar series in imaging and drug discovery, as well as a grant writing program focused on specific needs in our cancer's center's catchment area.