Core C Cohort Administration and Biospecimen Core

队列管理和生物武器核心(核心C)的目的是协调努力 和工作人员，为新一批参与者的招聘、登记、保留和抽样提供便利； 处理、跟踪和存储参与者的生物检疫；并将粪便和拭子样本送到林奇博士的 加州大学旧金山分校(核心D)的实验室进行微生物组分析，血浆样本送到奥恩比博士在佐治亚州的实验室 大学(核心E)的IgE分析和粪便和母乳样本的质谱学核心位于 密歇根州立大学(MSU)为这一更新项目-微生物区系和过敏性哮喘-进行脂质分析 《精确预防》(MAAP2)。该核心设施目前充当中央处理实验室和 从最初的P01研究参与者那里获得的所有生物和环境样本的信息交换中心， 《微生物、过敏、哮喘和宠物》(MAAP)研究。此核心设施还用作长期 保存标本(血浆、母乳、粪便、尿液、DNA、RNA、灰尘)，以供正在进行和未来的研究使用。 该实验室在执行目前为该核心提出的所有任务方面拥有丰富的经验 求婚。队列管理和生物学家核心对这个项目小组的总体目标至关重要 应用程序，因为它代表新出生队列的管理和监测部门，其样本将 通知所有四个项目。核心C将负责编程和协调技术方面的 为项目协调工作人员提供这些努力的方向的招聘和留用。核心C将指导 项目1和项目2将实施的参与者招聘和留用的方案方面。在……里面 此外，所有项目都将依赖核心C来处理、跟踪、储存和运输粪便、拭子、母乳和血浆 样本。通过集中队列管理活动，队列管理和生物量监测中心将 提供效率、一致性和可靠性。生物胺处理的集中化将提供熟练的 实验室工作人员在样品处理方案方面经验丰富，消除了重复劳动。核心C将 保留监测招聘和留用以及生物菌素鉴定所需的方案编制人员， 存储和分发。核心由金·伍德克罗夫特博士领导，他有15年的 指导HFHS分子流行病学研究实验室的经验。克里斯汀·约瑟夫博士，威尔 还在核心部门的征聘和留用监测方面发挥领导作用。约瑟夫博士有超过一位 在观察性研究和临床试验以及招募和保留研究方面有十年经验 参与者。

The purpose of the Cohort Administration and Biospecimen Core (Core C) is to provide coordination of efforts and staff to facilitate the recruitment, enrollment, retention and sampling of participants in the new cohort; to process, track and store participant biospecimens; and, to deliver stool and swab samples to Dr. Lynch's laboratory at UCSF (Core D) for microbiome analyses, plasma samples to Dr. Ownby's laboratory at Georgia University (Core E) for IgE analysis and stool and breastmilk samples to the Mass Spectrometry Core at Michigan State University (MSU) for lipid analysis for this renewal project `Microbiota and Allergic Asthma Precision Prevention' (MAAP2). This Core facility currently acts as the central processing laboratory and clearinghouse for all biological and environmental samples obtained from study participants in the initial P01, the `Microbes, Allergy, Asthma & Pets' (MAAP) study. This Core facility also serves as a repository for long-term storage of specimens (plasma, breast milk, stool, urine, DNA, RNA, dust) for use in ongoing and future studies. This laboratory has substantial experience performing all the tasks that are proposed for this Core in the present proposal. The Cohort Administration and Biospecimen core is essential to the overall goals of this PPG application as it represents the management and monitoring arm for the new birth cohort, whose samples will inform all four projects. Core C will be responsible for programming and coordinating technical aspects of recruitment and retention that provide Project Coordination staff with direction in these efforts. Core C will direct the programmatic aspects of participant recruitment and retention that Project 1 and Project 2 will implement. In addition, all projects will rely on Core C to process, track, store and ship the stool, swab, breastmilk and plasma samples. By centralizing cohort management activities, the Cohort Administration and Biospecimen Core will provide efficiency, consistency, and reliability. The centralization of biospecimen handling will provide skilled laboratory staff experienced in the sample processing protocols, eliminating duplication of effort. Core C will retain the programming staff needed for monitoring recruitment and retention, and for biospecimen identification, storage, and distribution. The Core is under the leadership of Kim Woodcroft, PhD, who has 15 years of experience in directing the Molecular Epidemiology Research Laboratory at HFHS. Christine Joseph, PhD, will also provide leadership in the recruitment and retention monitoring aspects of the Core. Dr. Joseph has over a decade of experience in observational studies and clinical trials, and in recruitment and retention of research participants.