EnamExcel: Iteratively develop the world's first varnish that regenerates and regrows human enamel and transforms global oral health.

在全球范围内，口腔健康状况不佳和口腔疾病造成4500亿英镑的损失，影响超过35亿人。牙釉质侵蚀是这些疾病的主要原因，影响了世界上近50%的人口。有证据表明，口腔健康状况不佳也可能与糖尿病、心血管并发症和肺炎等非传染性疾病有关。然而，目前的治疗方法，如氟化物保护漆和再矿化溶液，只能缓解牙釉质退化的症状。目前还没有解决方案可以有效地再生牙釉质与无毒的化合物，易于使用，并产生可比的结构和机械性能，以病人友好的方式。Mintech已经开发了一种正在申请专利的化合物和工艺，以创建一个局部清漆的牙齿，可以再生牙釉质。这一突破性创新有可能取代预防性氟化物保护漆，再生被侵蚀的牙釉质，并显着减少全球口腔健康疾病的负担。为了实现这一目标，该拨款提案旨在使Mintech目前的原型进入市场就绪状态，并为商业化做好准备。随着该项目的成功实施，Mintech的牙釉质再生清漆将彻底改变口腔保健，并改善全球数百万人的生活质量。

Globally, poor oral health and oral diseases are costing £450B and affecting over 3.5B people. Enamel erosion is a major contributor to these conditions, affecting almost 50% of the world's population. Evidence suggests that poor oral health may also be linked to non-communicable diseases such as diabetes, cardiovascular complications, and pneumonia.However, current treatments such as fluoride varnishes and remineralisation solutions only alleviate the symptoms of receding enamel. There is currently no solution available that can effectively re-grow enamel with non-toxic compounds that are easy to use and produce comparable structures and mechanical properties in a patient-friendly manner.Mintech has developed a patent-pending compound and process to create a topical varnish for teeth that can regrow enamel. This breakthrough innovation has the potential to replace preventative fluoride varnishes, regenerate eroded dental enamel, and significantly reduce the global burden of oral health diseases. To achieve this goal, this grant proposal aims to bring Mintech's current prototype into a market-ready state and prepare it for commercialisation. With the successful implementation of this project, Mintech's enamel-regenerating varnish could revolutionise oral healthcare and improve the quality of life for millions of people worldwide.