Brain Injury Knowledge Ontology (BIKO): Identifying Metadata Variance in Traumatic Brain Injury Therapy Studies

项目摘要 在美国，创伤性脑损伤是发病率和死亡率的重要原因，但没有 这种伤的治疗方法虽然一些治疗和程序已被认为是成功的， TBI治疗在临床前研究中取得的许多成功并没有转化为人类研究。一 检验这一挑战的方法是调查相关文献中的方法差异。这 一项提案旨在使用创伤性脑损伤（TBI）治疗论文中使用的实验方法和结果 通过以下三个目标创建一个度量来比较多个物种之间的方法学差异：1. 培训阶段1：建立脑损伤知识本体（BIKO），这是一个标准化的本体， 实验设计参数和结果。2.培训阶段1：创建一个知识库，BIKO基础， TBI治疗发现的实验设计参数（方法）和科学声明（结果） 文学3.训练阶段2：比较假设导致不同结果的实验差异 使用BIKO在TBI研究/文献中的多个种属之间进行比较。项目完成后， 更清楚地了解过去临床前TBI治疗的成功及其如何与临床结果保持一致， 加速发现人类患者TBI的成功疗法。

Project Summary Traumatic brain injury is a significant cause of morbidity and mortality in the United States, yet there is no approved therapy for this injury. Although several therapies and procedures have been deemed successful for TBI treatment in preclinical research studies, many of these successes did not translate to human studies. One way to examine this challenge is to investigate the methodological variances in the associated literature. This proposal aims to use experimental methods and outcomes used in traumatic brain injury (TBI) therapy papers to create a metric to compare the methodological variance between multiple species by following three aims: 1. Training Phase 1: Establish the Brain Injury Knowledge Ontology (BIKO), a standardized ontology to define experimental design parameters and outcomes. 2. Training Phase 1: Create a knowledge base, BIKO base, of experimental design parameters (methods) and scientific claims (results) from the TBI treatment discovery literature. 3. Training Phase 2: Compare experimental differences hypothesized to lead to distinct outcomes between and across multiple species in TBI studies/literature using the BIKO. Upon completion, this project will provide a clearer understanding of past preclinical TBI therapy success and how it aligns to clinical outcomes to accelerate the discovery of successful therapies for TBI in human patients.