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Brain Injury Knowledge Ontology (BIKO): Identifying Metadata Variance in Traumatic Brain Injury Therapy Studies

脑损伤知识本体（BIKO）：识别创伤性脑损伤治疗研究中的元数据方差

基本信息

批准号：
10685323
负责人：
MONIQUE SURLES-ZEIGLER
金额：
$ 10.77万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10685323
关键词：
Acceleration Age Algorithms Animal Model Brain Brain Injuries Breeding Cell Death Clinical Clinical Research Clinical Sciences Clinical Trials Common Data Element Communities Cytidine Diphosphate Choline Data Databases Dimensions Equipment Experimental Designs Future Gender Goals Human Injury Knowledge Knowledge Extraction Laboratories Left Literature Measures Metadata Methodology Methods Modeling Morbidity - disease rate Names Natural Language Processing Ontology Organism Outcome Outcome Measure Paper Patients Pharmaceutical Preparations Phase Physiological Processes Procedures Progesterone PubMed Publications Publishing Reaction Reagent Reporting Research Research Personnel Resources Role Science Scientist Standardization Statistical Methods TBI treatment Techniques Testing Therapeutic Studies Time Training Translating Traumatic Brain Injury United States Visualization analytical tool base clinical efficacy drug discovery evidence base graph theory improved instrument knowledge base mortality natural hypothermia neurochemistry pre-clinical pre-clinical research pre-clinical therapy preclinical study research study sex success text searching therapeutically effective tool

项目摘要

Project Summary Traumatic brain injury is a significant cause of morbidity and mortality in the United States, yet there is no approved therapy for this injury. Although several therapies and procedures have been deemed successful for TBI treatment in preclinical research studies, many of these successes did not translate to human studies. One way to examine this challenge is to investigate the methodological variances in the associated literature. This proposal aims to use experimental methods and outcomes used in traumatic brain injury (TBI) therapy papers to create a metric to compare the methodological variance between multiple species by following three aims: 1. Training Phase 1: Establish the Brain Injury Knowledge Ontology (BIKO), a standardized ontology to define experimental design parameters and outcomes. 2. Training Phase 1: Create a knowledge base, BIKO base, of experimental design parameters (methods) and scientific claims (results) from the TBI treatment discovery literature. 3. Training Phase 2: Compare experimental differences hypothesized to lead to distinct outcomes between and across multiple species in TBI studies/literature using the BIKO. Upon completion, this project will provide a clearer understanding of past preclinical TBI therapy success and how it aligns to clinical outcomes to accelerate the discovery of successful therapies for TBI in human patients.

项目摘要在美国，创伤性脑损伤是发病率和死亡率的一个重要原因，但没有批准了这种损伤的治疗方法。尽管有几种治疗方法和程序被认为是成功的在临床前研究中，这些成功中的许多并没有转化为人类研究。一检查这一挑战的方法是调查相关文献中的方法论差异。这该提案旨在使用创伤性脑损伤(TBI)治疗论文中使用的实验方法和结果通过以下三个目标创建一个度量来比较多个物种之间的方法差异：1. 培训阶段1：建立脑损伤知识本体(BICO)，定义一个标准化的本体实验设计参数和结果。2.培训阶段1：创建一个知识库、Biko库、来自脑损伤治疗发现的实验设计参数(方法)和科学声明(结果) 文学。3.培训阶段2：比较假设导致不同结果的实验差异在使用Biko的TBI研究/文献中的多个物种之间和跨物种。建成后，这一项目将更清楚地了解过去临床前脑损伤治疗的成功，以及它如何与临床结果相一致加速发现治疗人类脑损伤的成功疗法。