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HABS-HD - Core G - Development Core

HABS-HD - Core G - Development Core
HABS-HD - 核心 G - 开发核心
批准号:
10493851
负责人:
OZIOMA C OKONKWO
金额:
$112.06万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-09-30 至 2027-08-31

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中文摘要
翻译
HABS-HD开发核心-摘要 阿尔茨海默病(AD)和AD相关疾病(ADRD)的负担不成比例 代表性不足的群体(URG),特别是非裔美国人和西班牙裔人口。此超额AD/ADRD 鉴于年长的URG成年人,发病率及其伴随的社会经济成本预计会变得更大 美国人口中迅速扩大的一部分。具体而言,流行病学预测表明,通过 2060年美国将变得相当“非白人”,非洲人的比例增加了42%就是明证 拉美裔美国人的比例增加了114%,而西班牙裔人的比例下降了8.2% 非西班牙裔白人的比例。鉴于美国日益多样化的现实,迫切需要 策划教育机会,培养多样化的劳动力,以满足国家的生物医学, AD/ADRD的行为、临床和翻译需求。这样的机会将有助于确保提供 一批具有不同民族文化/语言和文化能力的专业人员准备研究, 评估、诊断和治疗患有ADRDS的老年人URG。在这个时间点上,需要这样一项倡议, 进一步强调这一事实的是,尽管联邦一级正在努力促进 在研究职业中,代表性不足仍然是一个长期存在的问题,最近的报告证明了这一点 来自国家科学基金会和其他人,例如,来自URG背景的人 仅占终身教职神经科学教师的5%,尽管在美国占比要大得多。 人口。因此,健康老龄化发展核心的首要目标是 研究-健康差距(HABS-HD)旨在招募、支持和提供有针对性的指导培训,以 年度URG实习生队列(研究生/专业学生、博士后研究员和早期职业 调查人员,称为HABS-HD研究员),以确保他们的研究熟练程度和文化 能力。我们将为他们提供概念知识库、实践技能和相关资源 这将有利于在AD/ADRD领域开展成功的独立研究事业。实习生 来自非URG背景,致力于健康差异研究的人也将被考虑 这一指导机会,因为我们的最终目标是解决目前在民族文化/语言方面缺乏 多元化和有文化能力的AD/ADRD员工队伍。为了实现我们的目标,发展核心将 解决以下具体目标:目标1:提供有针对性的指导培训方案,以确保研究 熟练程度和文化能力。目标2.衡量HABS-HD指导培训的有效性 程序。
英文摘要
HABS-HD DEVELOPMENT CORE - ABSTRACT There is a disproportionate burden of Alzheimer’s disease (AD) and AD related disorders (ADRDs) among underrepresented groups (URGs), especially African American and Hispanic populations. This excess AD/ADRD morbidity, and its attendant socioeconomic costs, is expected to get even larger given that older URG adults are a rapidly expanding segment of the U.S. population. Specifically, epidemiological projections indicate that by 2060 the U.S. will become considerably “non-white,” as reflected by a 42% increase in the percentage of African Americans and a 114% increase in the percentage of persons of Hispanic origin, compared to an 8.2% decrease in the proportion of non-Hispanic whites. In light of this reality of an increasingly diverse U.S., it is imperative to curate educational opportunities that foster the training of a diverse workforce to meet the nation’s biomedical, behavioral, clinical and translational needs in AD/ADRDs. Such opportunities would help ensure the availability of a pipeline of ethnoculturally/linguistically diverse and culturally competent professionals prepared to study, evaluate, diagnose, and treat URG older adults with ADRDs. The need for such an initiative, at this point in time, is further underscored by the fact that despite ongoing efforts at the federal level to facilitate the participation of URGs in research careers, underrepresentation remains a persistent problem as evidenced by recent reports from the National Science Foundation and others showing, as an example, that persons from a URG background comprise only 5% of tenure-track neuroscience faculty despite making up a significantly larger slice of the U.S. population. Therefore, the overarching objective of the Development Core of the Health & Aging Brain Study – Health Disparities (HABS-HD) is to recruit, support, and provide targeted mentored training to an annual cohort of URG trainees (graduate/professional students, postdoctoral fellows, and early career investigators, to be known as HABS-HD Fellows) to ensure their research proficiency and cultural competency. We will equip them with the conceptual knowledgebase, practical skillset, and allied resources that will be beneficial for launching successful independent research careers in the AD/ADRD field. Trainees from a non-URG background who have a commitment to health disparities research will also be considered for this mentorship opportunity, as our ultimate goal is to address the current lack of an ethnoculturally/linguistically diverse and culturally competent AD/ADRD workforce. To address our objective, the Development Core will address the following Specific Aims: Aim 1: Deliver a targeted mentored training program to ensure research proficiency and cultural competency. Aim 2. Measure the effectiveness of the HABS-HD mentored training program.
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KLOTHO and Resilience to Synaptic Dysfunction in Preclinical AD
  • 批准号:
    10587987
  • 项目类别:
  • 资助金额:
    $77.75万
  • 财政年份:
    2023
  • 负责人:
    OZIOMA C OKONKWO
  • 依托单位:
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk Cohort
  • 批准号:
    10064984
  • 项目类别:
  • 资助金额:
    $93.14万
  • 财政年份:
    2019
  • 负责人:
    OZIOMA C OKONKWO
  • 依托单位:
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk Cohort
  • 批准号:
    10318633
  • 项目类别:
  • 资助金额:
    $93.09万
  • 财政年份:
    2019
  • 负责人:
    OZIOMA C OKONKWO
  • 依托单位:
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk Cohort
  • 批准号:
    10082736
  • 项目类别:
  • 资助金额:
    $19.01万
  • 财政年份:
    2019
  • 负责人:
    OZIOMA C OKONKWO
  • 依托单位:
海外基金