ADDING 9-MONTH SUPPLEMENTAL FUNDS FOR TASK AREA 1 FOR TOPMED DCC

Trans-Omics for Precision Medicine（TOPMed）计划是NHLBI的领先计划，旨在通过开发科学数据资源和分析工具来加速基于组学的精准医学研究，使研究人员能够进行创新研究并在心脏，肺，血液和睡眠（HLBS）疾病方面取得突破，尽管数十年的投资仍然难以解决。TOPMed计划旨在补充NIH精准医学倡议（PMI）的活动。TOPMed计划利用NHLBI过去在不同临床研究队列和研究中的投资，建立一个平台，在该平台上，来自临床和环境测量、遗传学（全基因组） 测序（WGS））和功能基因组学（转录组学、表观基因组学、蛋白质组学和代谢组学）将被整合用于HLBS病症的系统生物学研究。TOPMed DCC合同计划的目标是为TOPMed计划提供行政、数据管理、分析和传播支持。

The Trans-Omics for Precision Medicine (TOPMed) Program is NHLBI’s leading program to accelerate -omics based precision medicine research by developing state-of-science data resources and analytical tools to enable investigators to conduct innovative research and achieve breakthroughs in heart, lung, blood, and sleep (HLBS) disorders that continue to remain intractable despite decades of investments. The TOPMed program is designed to complement the activities of the NIH Precision Medicine Initiative (PMI). The TOPMed program is capitalizing on NHLBI's past investments in diverse clinical research cohorts and studies to establish a platform on which the data from clinical and environmental measurements, genetics (whole genome sequencing (WGS)), and functional genomics (transcriptomics, epigenomics, proteomics, and metabolomics) will be integrated for systems biology study of HLBS disorders. The objective of the TOPMed DCC contract program is to provide administrative, data management, analysis, and dissemination support for the TOPMed program.