BLR&D Research Career Scientist Award Application

D.梅林博士，摘要 我们的研究计划旨在了解肠道炎症的发病机制和 制定肠道炎症性疾病的治疗策略，如IBD。我们的工作已经发表了 在声誉良好的期刊上始终如一地被广泛引用(2017年12月20日：H指数为45)。我们的实验室是 熟悉大量的技术，从纳米技术到分子生物学再到细胞生物学。超过一人 美国有100万成人和儿童，包括退伍军人管理局成员，患有IBD，约有5万人 根据美国克罗恩和结肠炎基金会的数据，每年都有新的确诊病例。VA IBD患者 与普通人群相比，结直肠癌的发病率要高得多(2.9%比0.1%，根据 国家卫生统计中心)。基于对疾病的更好理解的新的治疗策略 IBD的发病机制将改善退伍军人和非退伍军人患者的临床护理。我们 早就认识到跨学科研究在促进科学发现方面的价值 研究思路往往超越了单一学科或项目的范围。在这方面，我们促进了 对胃肠病学感兴趣的科学家/医生之间的跨学科合作研究 亚特兰大退伍军人医学中心和佐治亚州立大学生物医学科学研究所的科学家。 这些多学科合作旨在开发新的想法，以增强诊断和 治疗影响退伍军人管理局人群的结肠炎和结肠炎相关癌症。 1

D. Merlin Ph.D, Summary Our research program is directed toward understanding the pathogenesis of intestinal inflammation and formulating treatment strategies for intestinal inflammatory diseases such as IBD. Our work has been published consistently in reputable journals and cited extensively (December 20, 2017: h-index of 45). Our laboratory is familiar with a vast number of techniques, from nanotechnology to molecular biology to cell biology. Over one million adults and children in the US, including members of the VA population, suffer from IBD, with about 50,000 new cases diagnosed each year, according to the Crohn’s and Colitis Foundation of America. VA IBD patients have a much higher rate of colorectal cancer compared to the general population (2.9% vs. 0.1%, according to the National Center for Health Statistics). New therapeutic strategies based on a better understanding of the pathogenesis of IBD will improve the clinical care of veteran and non-veteran patients with this disorder. We have long recognized the value of interdisciplinary research in furthering scientific discovery, as important research ideas often transcend the scope of a single discipline or program. In this context, we have promoted collaborative interdisciplinary research between scientists/physicians with interests in gastroenterology at the Atlanta VA Medical Center and scientists at the Institute for Biomedical Sciences of Georgia State University. These multidisciplinary collaborations are intended to develop novel ideas that will enhance the diagnosis and treatment of colitis and colitis-associated cancers that affect the VA population. 1