Contaminants of emerging concern: An integrated approach for assessing impacts on the marine environment

CONTRAST将制定一个综合评估和基于效果的监测框架（IAF），以衡量cec对海洋环境的影响，为欧盟政策（即MSFD/WFD）的应用提供良好环境状况的衡量标准。IAF将涉及化学测量以及生物效应端点，这些端点将被优化，以检测cec在海洋环境中的存在及其影响程度。CONTRAST将通过使用化学物质优先排序方案来确定应在环境中测量哪些cec，从而确定对海洋生物构成最大威胁的cec。此外，哪些cec应用于实验室控制的实验，在那里将进行对生物系统和海洋生物多样性的影响。计算机、体外和体内生物分析结合组学将用于确定从化学优先方案中选择的CECs的主要毒性机制。这将提供重要的信息，说明在与环境有关的浓度下，氯化碳如何与海洋生物相互作用，并告知应在生物效应评估中使用哪些生物效应工具，以涵盖氯化碳产生的一系列毒性机制。CONTRAST将通过优化现有和开发新的生物标志物来解决这一问题，以便IAF包括生物标志物工具，以涵盖CECs产生的许多毒性机制。将利用一系列欧洲范围的案例研究来检验国际环境评估法是否适合测量化学品（包括氯代烃）对指示物种和生物多样性的影响。从实地测试和实验室研究中获得的知识将成为指导文件和政策简报的基础，以确定对海洋环境中的cec进行综合评估的最佳做法。此外，还将评估气候变化驱动因素对有机碳的相互作用，包括对有机碳分布、循环、命运、生物利用度和对海洋生物的毒性的影响。

CONTRAST will develop an integrated assessment and effect-based monitoring framework (IAF) to measure the impacts of CECs on the marine environment to provide a measure of Good Environmental Status for application in EU policy (i.e. MSFD/WFD). The IAF will involve chemical measurements together with biological effects endpoints that will be optimised to detect the presence and degree of effect of CECs in the marine environment. CONTRAST will identify the CECs that pose the greatest threat to marine life by using chemical prioritisation schemes to inform which of the CECs should be measured in the environment. Additionally, which CECs should be used in the laboratory-controlled experiments, where the effects on biological systems and marine biodiversity will be performed. A combination of in silico, in vitro and in vivo bioassays together with omics will be used to determine the principal mechanisms of toxicity of CECs selected from the chemical prioritisation schemes. This will provide important information on how CECs may interact with marine organisms at environmentally relevant concentrations and inform which biological effects tools should be used in the IAF to cover the range of toxicity mechanisms that CECs produce. CONTRAST will address this by optimising existing and developing new biomarkers, so that the IAF includes biomarker tools to cover many of the mechanism of toxicity produced by CECs. A series of European wide case studies will be used to test the suitability of the IAF to measure the effects of chemicals including CECs on indicator species and biodiversity. The knowledge gained from field testing and laboratory studies will form the basis for guidance documents and policy briefs on the best practices for performing an IAF on CECs in the marine environment. Furthermore, the interactions of climate change drivers on CECs will be evaluated including effects on CECs distribution, circulation, fate, bioavailability, and toxicity to marine life.