CHAPS Cohort Maintenance

摘要 儿童健康与空气污染研究（CHAPS）是NIEHS/EPA共同赞助的儿童健康研究项目之一。 环境健康中心，重点关注空气污染对在旧金山长大的儿童的影响。 位于加州的华金谷，是美国污染最严重的地区之一。CHAPS涉及招聘 和随访两个年龄特定的儿童队列，一个在子宫内招募的婴儿队列和一个儿童队列 在6-8岁时被招募。两个队列的主要研究目标是调查暴露于 环境空气污染，特别是多环芳烃和其他与交通有关的污染物， 免疫和代谢失调的影响我们在两个队列中招募了200多名儿童， 正在对他们进行为期两年的跟踪调查。我们收集了以下生物标志物数据： 人体测量;血压（BP）;儿童队列中的肺功能测定;血液样本中的免疫 调节、代谢功能和全身性炎症;以及氧化应激的尿测定。到目前为止， 我们的研究小组已经证实了一种新的表观遗传机制，通过这种机制，环境中的多环芳烃和其他 污染物通过叉头盒P3基因的超甲基化导致儿童过敏性疾病 （FOXP 3），B）证实暴露于环境多环芳烃与儿童肺功能下降有关， 和c）表明暴露于与交通有关的空气污染物，包括环境多环芳烃，与BP有关， 血红蛋白A1 c（HbA 1c）、年龄BMI和尿8-异前列腺素。我们在幼儿身上的发现是否会 随着儿童年龄的增长，预测未来的过敏性疾病和代谢综合征是一个重要的， 没有答案的问题为了解决这个问题，我们在环境流行病学的申请中提出 队列（EEC）资助以下具体目标：1）保留并继续跟踪CHAPS婴儿和 2）维持和加强数据管理基础设施; 3） 维护和丰富CHAPS生物标本库; 4）进行验证，试点和可行性 利用现有数据和样本进行研究; 5）鼓励数据共享。特征良好的CHAPS 队列研究提供了一个机会，研究交通相关的空气污染对健康的影响， 青少年在一个低收入，主要是拉丁裔社区。拟议的欧洲经济共同体将提供证据， 支持保护这些弱势群体健康的政策。

Abstract The Children’s Health and Air Pollution Study (CHAPS), one of the NIEHS/EPA co-sponsored Children’s Environmental Health Centers, has focused on the effects of air pollution on children growing up in the San Joaquin Valley of California, one of the most polluted areas in the country. CHAPS involves the recruitment and follow-up of two age-specific cohorts of children, an infant cohort recruited while in utero and a child cohort recruited at ages 6-8. The primary research goal for both cohorts is to investigate the effects of exposure to ambient air pollution, particularly polycyclic aromatic hydrocarbons (PAHs) and other traffic-related pollutants, on immune and metabolic dysregulation. We have recruited over 200 children in each of the two cohorts and are in the process of following them over a 2-year period. We have collected the following biomarker data: anthropometry; blood pressure (BP); spirometry in the child cohort; assays in blood samples for immune regulation, metabolic function, and systemic inflammation; and a urinary assay for oxidative stress. To date, our research team has a) confirmed a novel epigenetic mechanism by which ambient PAHs and other pollutants contribute to allergic disease in children through hypermethylation of the forkhead box P3 gene (FOXP3), b) confirmed that exposure to ambient PAHs is associated with reduced lung function in children, and c) shown that exposure to traffic-related air pollutants, including ambient PAHs, is associated with BP, hemoglobin A1c (HbA1c), BMI-for-age, and urinary 8-isoprostane. Whether our findings in young children will predict future allergic disease and metabolic syndrome as the children age is an important and currently unanswered question. To address this question we propose in our application for Environmental Epidemiology Cohort (EEC) funding the following specific aims: 1) to retain and continue to follow both CHAPS infant and child cohorts over the next 5 years; 2) to maintain and strengthen data management infrastructure; 3) to maintain and enrich the CHAPS repository of biospecimens; 4) to conduct validation, pilot, and feasibility studies using existing data and samples; and 5) to encourage data sharing. The well-characterized CHAPS cohorts provide the opportunity to study the health effects of traffic-related air pollution from birth through adolescence in a low-income, predominantly Latinx community. The proposed EEC will provide evidence in support of policies to protect the health of such vulnerable communities.