2022 James W. Freston Conference: Gastrointestinal Organoids and Engineered Organ Systems

项目摘要 本申请请求美国胃肠病学协会（阿加）的支持。弗雷斯顿 主题为“胃肠道类器官及工程化器官系统”的专题会议将于 2022年10月的华盛顿特区。NIH的资金将用于支持学员和年轻人的旅行奖励。 调查人员参加，介绍他们的科学，并与该领域的专家互动，最终期望 这些相互作用将导致新的科学合作和战略，以促进胃肠病学 research.本次会议解决了生物医学和制药界对更多 相关的基于人GI细胞的体外模型系统。几十年来，GI研究几乎完全依赖于 人类癌细胞系和动物模型，这限制了对人类GI生物学和疾病的理解。 创新的GI类器官和工程组织模型的最新发展现在允许使用更多 相关的人类细胞系统。本次会议将汇集专家在胃肠道器官细胞和 发育生物学和疾病病理学，与领先的生物工程师和组织芯片开发人员， 加强人类类器官/组织工程平台的使用，并促进GI的广泛和快速采用 研究社区。会议包括代表不同GI类器官的特邀专家发言人 模型和工程组织方法，学员和年轻研究人员的口头介绍， 从提交的摘要中选择，并根据摘要提交的海报演示。小尺寸 项目细节将为年轻的研究人员/学员提供许多机会， 已建立的专家。会议的目标是：1）提出新的和新兴的生物学见解 GI内稳态和疾病，以及体外GI器官系统工程的最新方法; 2） 为了增加科学对话，并为GI医生之间的科学合作提供机会，细胞 生物学家和生物工程师提高现有方法的可靠性，并以新的方式应用它们， 研究人GI组织生物学或模型GI疾病; 3）为了增加肝胆的相互作用， 胰腺和腔胃肠道科学家，并改善方法和方法之间的交叉受精 4）为学员和早期研究人员提供展示研究成果的机会 5）促进新的人类文化体系的采用 以及GI疾病研究者的创新平台和分析技术。最后一次会议将聚集 一个专家小组，就促进地理标志发展的方法提出共识建议 用于研究和发现应用的类器官和工程器官系统。

PROJECT SUMMARY This application requests support for an American Gastroenterological Association (AGA) James W. Freston Single Topic Conference entitled “Gastrointestinal Organoids and Engineered Organ Systems” to be held in Washington D.C. in October 2022. NIH funds will be used to support travel awards for trainees and young investigators to attend, present their science and interact with experts in the field, with the ultimate expectation that these interactions will lead to new scientific collaborations and strategies to advance gastroenterology research. This conference addresses a need in the biomedical and pharmaceutical communities for more relevant human GI cell-based in vitro model systems. For decades, GI studies have relied nearly exclusively on human cancer cell lines and animal models, which has limited understanding of human GI biology and disease. The recent development of innovative GI organoid and engineered tissue models now allows the use of more relevant human cell-based systems. This conference will bring together experts in GI organ cell and developmental biology and disease pathology, with leading bioengineers and tissue-chip developers to enhance the use of human organoid/tissue engineered platforms and foster broad and rapid adoption by the GI research community. The conference includes invited expert speakers representing divergent GI organoid models and engineered tissue approaches, oral presentations from trainees and young investigators to be selected from submitted abstracts, and poster presentations based on abstract submissions. The small size and program details will provide numerous opportunities for young investigator/trainees to interact with established experts. The GOALS of the conference are: 1) To present new and emerging biological insights into GI homeostasis and disease, and state-of-the-art methodologies to engineer in vitro GI organ systems; 2) To increase scientific dialogue and provide opportunities for scientific collaboration between GI physicians, cell biologists, and bioengineers to improve the reliability of existing approaches and apply them in novel ways to study human GI tissue biology or model GI diseases; 3) To increase the interaction of hepatobiliary, pancreatic, and luminal GI scientists and improve cross-fertilization of approaches and methodologies between these groups; 4) To provide opportunities for trainees and early stage investigators to present their research and network with established investigators; and 5) To facilitate the adoption of novel human culture systems and innovative platforms and analytic technologies by GI disease investigators. A final session will assemble an expert panel to make consensus recommendations on approaches to enhance the development of GI organoids and engineered organ systems for research and discovery applications.