Spatial repellents to reduce the outdoor transmission of malaria

摘要 尽管对中断户外疟疾的公共卫生干预措施的认识和迫切需要 在传播方面，目前还没有这种行之有效的干预措施。经氟氰菊酯处理的麻布条(TTHFS) 提供承诺，展示了坦桑尼亚环境中蚊子叮咬的六个多月的威慑作用。这个项目 寻求通过对坦桑尼亚研究的荟萃分析来澄清和推进TTHFS的证据基础，半 在泰国和柬埔寨进行实地和实地测试，以及在柬埔寨进行用户可接受性研究，以便为未来提供信息 研究和干预设计。 目的1：确定TTHFS的特性与其保护作用的关系 坦桑尼亚的时光。我假设最优的反氟氰菊酯浓度、布条尺寸和温度 TTHFS的范围可以从坦桑尼亚之前的研究中确定，这对高水平的 温度和相对湿度可以量化。 目的2：研究TTHFS在泰国和柬埔寨户外长期使用的防护效果 条件。我假设在坦桑尼亚有效的TTHFS在 针对泰国和柬埔寨疟疾媒介的非常不同的环境，具有相似的温度和 湿度对药效持续时间的影响。 目标3：建立用户可接受性，并确定TTHFS使用的可修改障碍 柬埔寨的护林员和森林游行者。我假设柬埔寨的护林员和森林探险者 会发现TTHFS可以接受，因为它们有能力减少蚊子叮咬，但会对 考虑到他们在TTHFS方面的有限经验，他们将优先考虑TTHFS的大小、形状和设计 TTHFS。 这项研究将为未来东南亚地区优化TTHFS的干预性研究提供参考 在这项K01研究之后。

ABSTRACT Despite the recognized and urgent need for public health interventions that interrupt outdoor malaria transmission, no such proven interventions are available. Transfluthrin-treated hessian fabric strips (TTHFS) offer promise, showing more than six months of mosquito bite deterrence in Tanzanian settings. This project seeks to clarify and advance the evidence base on TTHFS through meta-analysis of Tanzanian studies, semi- field and field testing in Thailand and Cambodia, and user acceptability studies in Cambodia to inform future studies and intervention designs. Aim 1: To determine the relationship between TTHFS characteristics and their protective efficacy over time in Tanzania. I hypothesize that an optimal transfluthrin concentration, fabric strip size, and temperature range for TTHFS can be identified from prior studies in Tanzania, and that impacts on efficacy caused by high temperature and relative humidity can be quantified. Aim 2: To investigate the protective efficacy of TTHFS over time in Thai and Cambodian outdoor conditions. I hypothesize that TTHFS that are efficacious in Tanzania will show similar levels of efficacy in a very different setting against Thai and Cambodian malaria vectors, with similar effects of temperature and humidity on the duration of efficacy. Aim 3: To establish user acceptability and identify modifiable barriers to TTHFS uptake among Cambodian forest rangers and forest goers. I hypothesize that Cambodian forest rangers and forest goers will find TTHFS acceptable due to their ability to reduce mosquito bites, but will be uncomfortable with the product given their limited experience with TTHFS and will have preferences on the size, shape, and design of TTHFS. This study will inform a future interventional study of an optimized TTHFS in Southeast Asia, to be performed subsequent to this K01 study.