A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device

项目摘要 Brimrose科技公司和合作伙伴约翰霍普金斯大学提出， 使用非侵入性超声神经调节识别新生儿缺氧缺血性脑病（HIE） 减少新生儿死亡和终身脑损伤。HIE是新生儿死亡的主要原因， 影响到发达国家每1 000例活产中的2-6例。我们的目标是调查并证明 应用神经电生理技术研究了不同程度缺氧和反复缺氧/缺糖对神经反应的影响 超声调制然后，我们将开发和验证一种超声神经调制， 光声成像设备原型用于监测新生儿脑损伤。该设备将用于 HIE的早期诊断，以便及时干预，最大限度地减少长期残疾。两 组织已经在霍普金斯建立了一个强大的研究团队和联合操作实验室， 这系统.由于目前方法的种种局限性，迫切需要对新生儿缺氧缺血性脑病进行早期诊断 诊断试剂盒，以便能够迅速进行治疗干预。没有早期诊断程序， 临床上可用于治疗HIE的设备。因此，我们的建议解决了一个关键的未满足的需求。

PROJECT SUMMARY The Brimrose Technology Corporation and partner, The Johns Hopkins University, propose using non-invasive ultrasound neuromodulation to identify hypoxic-ischemic encephalopathy (HIE) in newborns to reduce death and lifelong brain injury. HIE is the leading cause of neonatal death and impacts 2-6 of every 1,000 live births in the developed world. Our goal is to investigate and demonstrate the effect of graded hypoxia and repeated oxygen/glucose deprivation on neural response using ultrasound modulation. We will then develop and validate an ultrasound-neuromodulation coupled with photoacoustic-imaging device prototype to monitor neonatal brain injury. This device will be used for early diagnosis of HIE to enable timely intervention, which minimizes long-term disability. The two organizations have established a strong research team and joint operating lab at Hopkins to develop this system. Due to various limitations of current methods, there is an urgent need for an early HIE diagnostic kit to enable prompt therapeutic interventions. There are no early diagnostic procedures or devices available in the clinic for HIE. Hence, our proposal addresses a critical unmet need.