Northern California Acute Care Research Consortium (NORCARES)

创建了创新紧急护理临床试验网络的战略(SIREN)，以支持进行高质量的多中心临床试验，以改善神经系统、心脏、呼吸、血液和创伤紧急事件患者的预后。在本申请中，我们建议北加州急性护理研究联盟(NORCARES)作为新的警报器中心，具有联合中心和M-PI结构，其中包括UC Davis(Daniel Nishijima，MD)、Stanford(Karen Hirsch，MD)和UC San Francisco(Robert Rodriguez，MD)。这三家机构和个人投资机构非常适合领导一个中心，在过去20年中，它们的研究计划和生产率取得了广泛和持续的增长，并拥有强大的研究基础设施，以促进患者登记参加试验。NORCARES包括30个Spoke和7个EMS系统，分布在加利福尼亚州北部和我们的调查人员之前与之合作的邻近地区。我们选择了Spokes和EMS机构，这些机构拥有丰富的研究经验和基础设施，吸收了大量具有不同种族和民族背景、城乡地理以及学术和社区医院的患者。在整个NORCARES枢纽，每年有超过180万急诊，520,000个院前911现场运输，21,000个创伤入院。与美国人口相比，我们的中心服务于更大比例的黑人、亚洲人、夏威夷原住民和太平洋岛民以及西班牙裔ED患者。我们将确保NORCARES为我们的Spokes和EMS机构提供坚实的研究基础设施、培训和监督。我们的中心将招收大量的研究对象，保持良好的临床实践，遵守研究法规，并遵守质量控制活动。我们将在所有研究活动中与其他SIREN中心、数据协调中心、临床协调中心和联邦合作伙伴合作。我们将实施创新的初级教师培训计划，将初级学者转变为能够设计和领导急救试验的试验调查员。我们将努力促进医学教师中女性和代表性不足的少数族裔的职业生涯，他们占我们关键人员的44%。凭借卓越的基础设施和创新的协作计划，我们建议的中心处于独特的地位，可以在SEREN试验中增加登记人数，促进患者群体和教师的公平性和多样性。

The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) was created to enable conduct of high-quality, multicenter clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, hematologic, and trauma emergency events. In this application, we propose the Northern California Acute Care Research Consortium (NORCARES) as a new SIREN Hub, with a Co-Hub and M-PI structure that includes UC Davis (Daniel Nishijima, MD, MAS), Stanford (Karen Hirsch, MD), and UC San Francisco (Robert Rodriguez, MD). These three institutions and PIs are well suited to lead a Hub, having demonstrated broad and sustained growth in their research programs and productivity over the past 20 years with robust research infrastructure to facilitate patient enrollment into trials. NORCARES includes 30 Spokes and 7 EMS systems across Northern California and adjacent areas with whom our investigators have previously collaborated. We have selected Spokes and EMS agencies with extensive research experience and infrastructure, drawing on large patient volumes with diverse racial and ethnic backgrounds, urban and rural geography, and academic and community hospitals. Annually across the NORCARES Hub, there are over 1.8 million ED visits, 520,000 prehospital 911 scene transports, and 21,000 trauma admissions. Compared to the US population, our Hub serves larger proportions of Black, Asian, Native Hawaiian and Pacific Islander, and Hispanic ED patients. We will ensure that NORCARES provides solid research infrastructure, training and oversight to our Spokes and EMS agencies. Our Hub will enroll substantial numbers of research subjects, maintain Good Clinical Practices, adhere to research regulations, and comply with quality control activities. We will collaborate with the other SIREN Hubs, the Data Coordinating Center, the Clinical Coordinating Center, and federal partners in all research activities. We will implement an innovative Junior Faculty Training Program to transform junior scholars into trial investigators, capable of designing and leading emergency care trials. We will seek to promote the careers of women and under-represented minorities in medicine faculty, who constitute 44% of our key personnel. With outstanding infrastructure and an innovative collaborative plan, our proposed Hub is uniquely positioned to boost enrollment and promote equity and diversity of patient populations and faculty in SIREN trials.