Core D - Data Management and Bioinformatics Core

项目摘要/摘要 Sybil数据管理和生物信息学核心(DMBC)将在所有阶段支持中心的使命 通过跟踪项目和实验、促进可重复性分析、开发 生物信息工具，并确保数据和资源的获取和传播。研究将会加快 通过使用全面的 数据管理平台，连接所有项目和方案的核心。DMBC将实施 全面的工作流程和质量控制管道，以确保生成的数据的严密性和可重复性 整个Sybil财团。方案数据和资源将通过公共储存库传播 以及由核心开发和维护的中心网站。优化了DMBC的工作流程 并在前一届FluOMICS财团期间得到改进，通过促进合作和交流 核心和项目之间的数据、生物信息学工具和模型，形成了目前的综合结构。 DMBC的一个重要目标将是开发促进数据使用和再利用的公共工具 由Sybil计划和更广泛的科学界共同产生。系统级的可用性 近年来，传染病领域的数据增长到了前所未有的水平，特别是在 正在进行的新冠肺炎大流行。然而，由于缺乏可访问和易于使用的工具来提供 统一访问和执行大规模数据集的荟萃分析，这些数据集具有巨大的传染病潜在风险 为设计和开发新的治疗策略提供信息的组学数据集可能仍未实现。至 为了克服这一障碍，DMBC计划建立Coronasscape，这是一种新工具，使研究人员能够 将他们实验的网络和路径特征与公开可用的宿主-病原体数据集进行匹配 并利用这些数据来克服一个不断进步的领域正在出现的挑战。建立在高度 之前由DMBC开发的成功的Metascape平台，Coronascape承诺推动 利用和再利用可公开获得的大量SARS-CoV-2数据。

PROJECT SUMMARY/ABSTRACT The SYBIL Data Management and Bioinformatics Core (DMBC) will support the Center's mission at all stages of research and publication by tracking projects and experiments, facilitating reproducible analysis, developing bioinformatic tools, and ensuring access and dissemination of data and resources. Research will be accelerated by the centralization of primary and processed data, models, workflows, and pipelines using a comprehensive data management platform to connect all Projects and Cores of the program. The DMBC will implement comprehensive workflows and quality control pipelines to ensure rigor and reproducibility of the data generated throughout the SYBIL Consortium. Program data and resources will be disseminated through public repositories and a Center website developed and maintained by the Core. The workflow of the DMBC has been optimized and improved during the previous FluOMICS Consortium, through facilitating cooperation and the exchange of data, bioinformatics tools and models between Cores and Projects, resulting in the present integrated structure. An important goal of the DMBC will be the development of public tools that facilitate the use and reuse of data generated by both the SYBIL program and the broader scientific community. The availability of systems-level data in the infectious disease field has grown to unprecedented levels in recent years, particularly during the ongoing COVID-19 pandemic. However, due to a lack of accessible and easy-to-use tools that provide consolidated access and perform meta-analyses of large-scale datasets, the vast potential for infectious disease OMICs datasets to inform design and development of new therapeutic strategies likely remains unrealized. To help overcome this barrier, the DMBC plans to establish Coronascape, a new tool that enables researchers to match the network and pathway signatures of their experiments to publicly available host-pathogen data sets and leverage those data to overcome emerging challenges of an advancing field. Building on the highly successful Metascape platform previously developed by the DMBC, Coronascape promises to promote the utilization and reuse of the vast amounts of SARS-CoV-2 data that are publicly available.