Administrative Core

项目摘要/摘要-行政核心 这一创新的集成系统生物学应用寻求进一步描述复杂的宿主/病原体 发生在肺泡水平的相互作用，导致对严重肺炎的治疗无效。 SCRIPT2系统生物学中心有意进行多学科合作，增加了相互作用的复杂性 并要求采取集中的方法，以促进实现该系统生物学中心的目标。这个 SCRIPT2系统生物学中心研究议程的主要前提是迭代方法 基于高通量组学方法和数学模型结果的宿主/病原体相互作用 结果的结果。因此，我们预计先前的结果将推动后续的实验。融合便利化 这些随后在不同核心和调查人员之间进行的实验将是主要责任 管理核心。行政核心还将确保项目和核心产生的数据 以对更大的肺炎和传染病社区有用的形式传播 研究人员。行政核心将通过四个具体目标实现这些目标： 目标1.支持项目调查人员、核心领导和其他U19系统之间的沟通 生物中心调查人员和NIAID项目工作人员。行政核心将负责 协调整个中心活动范围内的沟通，包括与 多学科SCRIPT2调查人员，与其他U19中心，以及NIH/NIAID项目工作人员。 目标2.为共同资源的分配和传播提供一个结构 信息，以及监管监督以及预算和人力资源管理 项目调查员和核心领导。我们预计之前的建模结果将推动后续分析 或数据/样本收集。整合和促进不同核心之间的这些后续分析 调查人员将是行政核心的主要责任。 目标3.通过出版物传播项目调查员的发现， 以及向其他机构和调查人员分享材料和原始数据，包括 通过NIAID指导的公共数据库/储存库。我们致力于使我们的数据可供查找， 可访问性、互操作性和可重用性(公平)。 目标4.营造跨学科协作研究的本地和外部环境 指导学员以系统生物学的方法处理肺炎、其他传染病、 以及其他危重疾病。我们认为，SCRIPT2系统生物学、多组学和数学 重症肺炎的建模方法与其他感染和其他危重疾病相关。《管理员》 CORE将组织一系列当地和外联活动，以促进这一做法。

Project Summary/Abstract – Administrative Core This innovative integrated systems biology application seeks to further delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. The SCRIPT2 Systems Biology Center is intentionally multidisciplinary, increasing the complexity of interactions and mandating a centralized approach to facilitate accomplishing the goals of this Systems Biology Center. The major premise of the SCRIPT2 Systems Biology Center research agenda is an iterative approach to host/pathogen interactions based on results of high throughput omics approaches and mathematical modeling of the results. We therefore expect that prior results will drive subsequent experiments. Integration and facilitation of these subsequent experiments between the different Cores and investigators will be the primary responsibility of the Administrative Core. The Administrative Core will also ensure that data generated by the Projects and Cores are disseminated in formats that are useful to the larger community of pneumonia and infectious diseases researchers. The Administrative Core will accomplish these objectives in four specific aims: Aim 1. To support communication between Project Investigators, Core Leaders, other U19 Systems Biology Center Investigators, and NIAID Program Staff. The Administrative Core will be responsible for coordinating communication across the entire range of Center activities, including internal relationships with the multidisciplinary SCRIPT2 investigators, with other U19 Centers, and with NIH/NIAID program staff. Aim 2. To provide a structure for the distribution of common resources and the dissemination of information, as well as regulatory oversight and budgetary and personnel resource management, to the Project Investigators and Core Leaders. We expect that prior modeling results will drive subsequent analyses or data/sample collection. Integration and facilitation of these subsequent analyses between the different Cores and investigators will be the primary responsibility of the Administrative Core. Aim 3. To disseminate the discoveries made by Project Investigators through publications, presentations, and the sharing of materials and raw data to other institutions and investigators, including via NIAID-directed public databases/repositories. We are committed to making our data Findable, Accessible, Interoperable, and Reusable (FAIR). Aim 4. To foster a local and external environment of collaborative interdisciplinary research and mentoring of trainees to promote a systems biology approach to pneumonia, other infectious diseases, and other critical illnesses. We believe that the SCRIPT2 Systems Biology multi-omics and mathematical modeling approach to severe pneumonia is pertinent to other infections and other critical illnesses. The Admin Core will organize a suite of local and outreach activities to foster this approach.